Joeres R P, Vermeulen N P, Breimer D D
Medizinische Universitätsklinik, Würzburg, FRG.
Pharmacology. 1988;36(3):210-6. doi: 10.1159/000138386.
Pharmacokinetic parameters of hexobarbital were estimated in rats after hepatic portal infusion of a 10-mg dose. Infusion during 10 min resulted in an area under the blood concentration-time curve (AUC) of 556 +/- 83 micrograms.min/ml and a clearance of 83 +/- 13 ml/min.kg, whereas infusion of the same dose during 40 min resulted in values of 272 +/- 36 micrograms.min/ml and 169 +/- 30 ml/min.kg, respectively (mean values +/- SD, n = 3). Infusion during 15 and 20 min provided intermediate values. The decrease of the AUC and the increase of the blood clearance of hexobarbital following decreasing infusion rates clearly indicate nonlinear pharmacokinetics related to the hepatic inflow concentration of hexobarbital.
在大鼠经肝门静脉输注10毫克剂量的己巴比妥后，对其药代动力学参数进行了估算。10分钟输注期间，血药浓度-时间曲线下面积（AUC）为556±83微克·分钟/毫升，清除率为83±13毫升/分钟·千克；而40分钟输注相同剂量时，AUC值为272±36微克·分钟/毫升，清除率为169±30毫升/分钟·千克（平均值±标准差，n = 3）。15分钟和20分钟输注得到中间值。随着输注速率降低，己巴比妥的AUC降低而血清除率增加，这清楚地表明了与己巴比妥肝内流入浓度相关的非线性药代动力学。
