Clauss W, Domokos G, Leng-Peschlow E
Institut für Veterinärphysiologie, Freie Universität Berlin, BRD.
Pharmacology. 1988;36 Suppl 1:104-10. doi: 10.1159/000138428.
The effect of the laxative component rhein on electrical properties and Cl transport was investigated in partially stripped epithelial sheets of rabbit distal colon under short-circuit conditions. Whereas mucosal rhein had no effect, serosally applied rhein stimulated electrogenic Cl secretion in a dose-dependent manner with a half-maximal stimulation at 0.05 mmol/l. The stimulation was partially reversible by serosal bumetanide. Indomethacin preincubation inhibited the effect of rhein, but did not prevent theophylline-induced Cl secretion. The results suggest a prostaglandin-mediated effect of rhein on the apical Cl conductance of the colonic cells.
