Sun J, Zhang D Y, Wang J, Lu Y Y
Comprehensive Liver Cancer Center, 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China.
Zhonghua Gan Zang Bing Za Zhi. 2021 Feb 20;29(2):188-192. doi: 10.3760/cma.j.cn501113-20190918-00341.
Neural precursor cells-expressed developmentally down-regulated protein-8 (NEDD8) is one of the important members of the ubiquitin family, which plays an important role in maintaining cell stability, cell cycle regulation, signal transduction, transcription, and translation, DNA repair, and tumorigenesis through covalently bound substrates (also known as neddylation modification). In recent years, studies have found that the dysfunction of NEDD8 and its related enzymes is common in liver diseases, and is widely involved in the biological processes of hepatitis, liver fibrosis, proliferation, invasion, apoptosis and autophagy of liver cancer cells. This article focuses on the research progress of NEDD8 in liver diseases.
神经前体细胞表达的发育下调蛋白8（NEDD8）是泛素家族的重要成员之一，它通过与底物共价结合（也称为NEDD8化修饰）在维持细胞稳定性、细胞周期调控、信号转导、转录和翻译、DNA修复以及肿瘤发生等过程中发挥重要作用。近年来，研究发现NEDD8及其相关酶的功能障碍在肝脏疾病中很常见，并广泛参与肝炎、肝纤维化、肝癌细胞增殖、侵袭、凋亡和自噬等生物学过程。本文重点阐述NEDD8在肝脏疾病中的研究进展。
