大鼠体内14C-大黄酸及14C-大黄酸蒽酮的代谢

Metabolism of 14C-rhein and 14C-rhein anthrone in rats.

作者信息

de Witte P, Lemli J

机构信息

Laboratorie voor Farmaceutische Biologie en Fytofarmacologie, Katholieke Universiteit, Leuven, Belgium.

出版信息

Pharmacology. 1988;36 Suppl 1:152-7. doi: 10.1159/000138435.

DOI:10.1159/000138435

PMID:3368514

Abstract

The two radioactive compounds were administered intracaecally to rats, and the recovery rates amounted to 89.9% for 14C-rhein and to 97.4% for 14C-rhein anthrone after 5 days. All organs and tissues showed for both compounds a significant clearance of radioactivity with exception of the kidneys where high levels persisted even after 5 days. Different metabolites could be detected in urine as well as in faeces where also nonanthraquinone fractions could be found.

摘要

将这两种放射性化合物经盲肠内给药于大鼠，5天后，14C-大黄酸的回收率为89.9%，14C-大黄酸蒽酮的回收率为97.4%。除肾脏外，所有器官和组织对这两种化合物的放射性均有显著清除，即使在5天后，肾脏中仍持续存在高水平的放射性。在尿液和粪便中均可检测到不同的代谢产物，其中也能发现非蒽醌部分。