Department of Radiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey.
Department of Radiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
Acta Cardiol. 2022 Feb;77(1):71-80. doi: 10.1080/00015385.2021.1887585. Epub 2021 Mar 8.
To evaluate the utility of cardiac magnetic resonance feature tracking-derived left ventricular strain in assessing cardiac dysfunction and investigate the correlation between left ventricular strain and myocardial T2* in patients with beta-thalassaemia major.
Forty-two patients with beta-thalassaemia major, having a mean age of 22.49 ± 8.48 years, and age-matched healthy controls were enrolled in the study. The observer drew regions of interest on the interventricular septum, and T2* decay curves were calculated accordingly. The short-axis cine images were used to derive left ventricular circumferential and radial strains, and the long-axis four-chamber and two-chamber images were used to assess left ventricular longitudinal strain.
The mean global left ventricular strains were lower in beta-thalassaemia major patients than the controls ( < 0.05). Left ventricular strains of beta-thalassaemia major patients with cardiac T2* values of > 20 ms were also significantly reduced compared with the controls ( < 0.05); there was no difference between the mean left ventricular ejection fractions of the two groups ( = 0.84). Cardiac T2* showed a weak correlation with left ventricular ejection fraction ( = 0.33, = 0.03), while the left ventricular circumferential strain showed a good positive correlation with cardiac T2* ( = 0.6, < 0.0001).
Compared with healthy controls, patients with beta-thalassaemia major, including those with myocardial T2* values of >20 ms, showed reduced global left ventricular strains. Left ventricular circumferential strain was positively correlated with myocardial T2*. Left ventricular strain analysis using cardiac magnetic resonance feature tracking may have utility in beta-thalassaemia major assessment.Key FindingsPatients with beta-thalassaemia major, including those with myocardial T2* values of >20 ms, had reduced global left ventricular strains.Cardiac T2* showed a weak correlation with left ventricular ejection fraction, while the left ventricular circumferential strain showed a good positive correlation with cardiac T2*.ImportanceLeft ventricular strain using cardiac magnetic resonance feature tracking might be used as an adjunct in assessing cardiac functions in beta-thalassaemia major.
评估心脏磁共振特征追踪衍生的左心室应变在评估心功能障碍中的效用，并探讨其与地中海贫血患者心肌 T2*之间的相关性。
本研究纳入了 42 名地中海贫血患者（平均年龄 22.49±8.48 岁）和年龄匹配的健康对照组。观察者在室间隔上画出感兴趣区，相应地计算 T2*衰减曲线。使用短轴电影图像得出左心室周向和径向应变，使用长轴四腔和两腔图像评估左心室纵向应变。
与对照组相比，地中海贫血患者的整体左心室应变较低（<0.05）。心脏 T2值>20ms的地中海贫血患者的左心室应变也明显低于对照组（<0.05）；两组的左心室射血分数平均值无差异（=0.84）。心脏 T2与左心室射血分数呈弱相关（=0.33，=0.03），而左心室周向应变与心脏 T2*呈良好的正相关（=0.6，<0.0001）。
与健康对照组相比，包括心脏 T2值>20ms 的地中海贫血患者，其整体左心室应变均降低。左心室周向应变与心肌 T2呈正相关。使用心脏磁共振特征追踪进行左心室应变分析可能对评估地中海贫血有一定的作用。
包括心脏 T2*值>20ms 的地中海贫血患者，其整体左心室应变均降低。
心脏 T2与左心室射血分数呈弱相关，而左心室周向应变与心脏 T2呈良好的正相关。
