A型肉毒毒素对帕金森病伴足部痉挛患者步态的影响。
Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia.
机构信息
Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
出版信息
Can J Neurol Sci. 2022 Jan;49(1):123-128. doi: 10.1017/cjn.2021.42. Epub 2021 Mar 9.
We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.
我们研究了肉毒毒素对伴有足部痉挛的帕金森病（PD）患者步态的影响。6 名患者接受了肉毒毒素 A 注射，并在基线、1 个月和 3 个月时通过 Burke-Fahn-Marsden 肌张力障碍评定量表（BFMDRS）、疼痛视觉模拟量表（VAS）、计时起立行走测试（TUG）、Berg 平衡测试（BBT）和 3D 步态分析进行评估。BFMDRS（p = 0.002）、VAS（p = 0.024）、TUG（p = 0.028）和 BBT（p = 0.034）均有改善。第 1 跖骨（p = 0.028）和中足（p = 0.018）的足部压力降低，表明肉毒毒素可减轻 PD 患者的肌张力障碍严重程度和疼痛，并改善行走时的足部压力。
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