Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Can J Neurol Sci. 2022 Jan;49(1):123-128. doi: 10.1017/cjn.2021.42. Epub 2021 Mar 9.
We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.
我们研究了肉毒毒素对伴有足部痉挛的帕金森病（PD）患者步态的影响。6 名患者接受了肉毒毒素 A 注射，并在基线、1 个月和 3 个月时通过 Burke-Fahn-Marsden 肌张力障碍评定量表（BFMDRS）、疼痛视觉模拟量表（VAS）、计时起立行走测试（TUG）、Berg 平衡测试（BBT）和 3D 步态分析进行评估。BFMDRS（p = 0.002）、VAS（p = 0.024）、TUG（p = 0.028）和 BBT（p = 0.034）均有改善。第 1 跖骨（p = 0.028）和中足（p = 0.018）的足部压力降低，表明肉毒毒素可减轻 PD 患者的肌张力障碍严重程度和疼痛，并改善行走时的足部压力。
