Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Faculty of Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
Toxins (Basel). 2023 Jan 17;15(2):81. doi: 10.3390/toxins15020081.
This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include the common motor disorders in PD such as tremor, focal foot dystonia, rigidity and freezing of gait (FOG). In the area of Parkinson tremor, two newly described evaluation/injection techniques (Yale method in USA and Western University method in Canada) offer efficacy with low incidence of hand and finger weakness as side effects. Blinded studies conducted on foot dystonia of PD indicate that botulinum toxin injections into toe flexors are efficacious in alleviating this form of dystonia. Small, blinded studies suggest improvement of Parkinson rigidity after botulinum toxin injection; proof of this claim, however, requires information from larger, blinded clinical trials. In FOG, the improvement reported in open label studies could not be substantiated in blinded investigations. However, there is room for further controlled studies that include the proximal lower limb muscles in the injection plan and/or use higher doses of the injected toxin for this indication.
这篇综述提供了关于肉毒毒素治疗帕金森病常见运动障碍的最新文献资料。综述的疾病包括帕金森病中的常见运动障碍，如震颤、局灶性足部痉挛、僵硬和冻结步态（FOG）。在帕金森震颤领域，两种新描述的评估/注射技术（美国耶鲁大学方法和加拿大西安大略大学方法）具有疗效，副作用发生率低，如手部和手指无力。对帕金森病足部痉挛的盲法研究表明，将肉毒毒素注射到脚趾屈肌中可有效缓解这种形式的痉挛。小型盲法研究提示肉毒毒素注射后帕金森病僵硬可改善；然而，需要来自更大规模、盲法临床试验的信息才能证实这一说法。在 FOG 中，开放性研究报告的改善无法在盲法研究中得到证实。然而，对于进一步的对照研究，包括在注射计划中纳入近端下肢肌肉和/或针对这一适应证使用更高剂量的注射毒素，仍有空间。
