一位 62 岁男性，新发水疱。
A 62-year-old man with new-onset bullae.
出版信息
Allergy Asthma Proc. 2021 Mar 1;42(2):175-179. doi: 10.2500/aap.2021.42.200055.
Abstract
Cutaneous blisters and/or bullae can occur in autoimmune disorders, infections, genetic diseases, and drug hypersensitivity. We present the case of a 62-year-old man with two autoimmune conditions who was admitted for antibiotic treatment of a lower extremity infection and suddenly developed a bullous rash. His physical examination was significant for tense, bullous lesions that involved his chin, palms, and inner thighs. Narrowing the differential diagnosis for patients with blistering skin lesions is imperative for timely and appropriate management.
摘要
皮肤水疱和/或大疱可发生于自身免疫性疾病、感染、遗传疾病和药物超敏反应中。我们报告了一例患有两种自身免疫性疾病的 62 岁男性，他因下肢感染接受抗生素治疗而入院，随后突然出现大疱性皮疹。他的体格检查显示紧张性大疱性病变，累及下巴、手掌和大腿内侧。缩小大疱性皮肤病变患者的鉴别诊断对于及时和适当的管理至关重要。
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本文引用的文献
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Acta Derm Venereol. 2020 Feb 29;100(4):adv00070. doi: 10.2340/00015555-3415.
2
Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature.药物诱导的线性 IgA 大疱性皮病：病例报告及文献复习。
Acta Derm Venereol. 2019 May 1;99(6):508-515. doi: 10.2340/00015555-3154.
3
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Front Med (Lausanne). 2018 Nov 2;5:296. doi: 10.3389/fmed.2018.00296. eCollection 2018.
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JAAD Case Rep. 2018 Oct 12;4(9):953-955. doi: 10.1016/j.jdcr.2018.07.013. eCollection 2018 Oct.
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