Snyder D A, Swartz M, Goldberg M F
J Pediatr Ophthalmol. 1977 Sep-Oct;14(5):286-9.
Two patients with Goldenhar syndrome developed corneal ulcers. Previous acid burn of the cornea and prolonged topical corticosteroid administration occurred in Patient 1. Predisposing ocular anomalies in patients with Goldenhar syndrome include corneal hypesthesia; keratoconjunctivitis sicca, and exposure secondary to eyelid colobomas, lacrimal gland and duct anomalies, dermoids and lipodermoids, and neurologic deficits. Serious ocular morbidity may be prevented by searching for and adequately treating these predisposing factors. It is possible that embryonic events contribute to ocular complications in Goldenhar syndrome, in part, by causing hypoplasia or abnormal function of the trigeminal and facial nerves.
两名患有Goldenhar综合征的患者发生了角膜溃疡。患者1曾有角膜酸烧伤史并长期局部使用皮质类固醇。Goldenhar综合征患者的眼部易患异常包括角膜感觉减退、干燥性角结膜炎，以及因眼睑缺损、泪腺和泪管异常、皮样瘤和脂质皮样瘤及神经功能缺损导致的暴露。通过寻找并充分治疗这些易患因素，可预防严重的眼部疾病。胚胎事件可能部分通过导致三叉神经和面神经发育不全或功能异常，从而引发Goldenhar综合征的眼部并发症。
