有机酸血症 COVID-19 感染的管理。
Management of COVID-19 infection in organic acidemias.
机构信息
Division of Genetic, Genomic, and Metabolic Disorders, Children's Hospital of Michigan, Detroit, Michigan, USA.
Discipline of Pediatrics, Central Michigan University, Mount Pleasant, Michigan, USA.
出版信息
Am J Med Genet A. 2021 Jun;185(6):1854-1857. doi: 10.1002/ajmg.a.62161. Epub 2021 Mar 8.
The COVID-19 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS-CoV-2 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID-19 infection. The SARS-CoV-2 virus does not appear to cause a more severe metabolic deterioration than is typical.
COVID-19 大流行已影响到全球各年龄段人群的健康和医疗。有多项报告和综述记录了儿科人群的影响较轻，发病率和死亡率降低，但仅有少数报告讨论了先天性代谢缺陷（IEM）患者中的 SARS-CoV-2 感染。在这里，我们报告了两例患有基础代谢紊乱的患者，丙酸血症和戊二酸血症 1 型，并讨论了他们的临床表现以及他们的感染和代谢管理。我们的报告表明，患有基础 IEM 的个体在 COVID-19 感染的情况下有发生代谢失代偿的风险。SARS-CoV-2 病毒似乎不会比典型情况导致更严重的代谢恶化。
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