Illum P, Bjerring P
Dept. of Otolaryngology, Aarhus University Hospital, Denmark.
Rhinology. 1988 Mar;26(1):19-24.
Hereditary hemorrhagic telangiectasia (Osler's disease) is a rare, inherited abnormality of the subepithelial vessels causing severe nose bleed as the most predominant symptom. The most efficient treatment has, until now, been dermoplasty of the nasal septum and cavity. There have been a few reports on treatment with CO2-, argon- or Nd-YAG-lasers, which have been encouraging. Ten patients with Osler's disease were treated for severe epistaxis. Three were treated with CO2-laser, two of these under general anaesthesia. Seven patients were treated with the argon laser under local anaesthesia. A variety of other sites were treated at the same time for functional or cosmetic reasons (mouth, face, fingers, rectum). Good results were obtained in eight cases. In three of the cases the observation period was more than two years. A second treatment has been necessary in three cases. Two other patients were treated recently, and it is too early to judge the results. The argon-laser is more convenient for this purpose than the CO2-laser. The method is quick and reliable and there is no need for hospitalization. The treatment can be repeated without permanent damage to the function of the nose.
遗传性出血性毛细血管扩张症（奥斯勒氏病）是一种罕见的、遗传性的上皮下血管异常疾病，最主要的症状是严重鼻出血。到目前为止，最有效的治疗方法是鼻中隔和鼻腔的皮肤成形术。有一些关于使用二氧化碳、氩或钕钇铝石榴石激光治疗的报告，结果令人鼓舞。对10例奥斯勒氏病患者进行了严重鼻出血的治疗。3例采用二氧化碳激光治疗，其中2例在全身麻醉下进行。7例患者在局部麻醉下接受氩激光治疗。出于功能或美容原因，同时对其他各种部位（口腔、面部、手指、直肠）进行了治疗。8例取得了良好效果。其中3例的观察期超过两年。3例需要进行第二次治疗。另外2例患者最近接受了治疗，目前判断结果还为时过早。为此，氩激光比二氧化碳激光更方便。该方法快速可靠，无需住院。治疗可以重复进行，不会对鼻子功能造成永久性损害。
