Rooij Tom van, Beekers Ines, Lattwein Kirby R, van der Steen Antonius F W, de Jong Nico, Kooiman Klazina
IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jun;68(6):2319. doi: 10.1109/TUFFC.2021.3064751. Epub 2021 May 25.
In the above article [1], the authors regret that there was a mistake in calculating the mol% of the microbubble coating composition. For all experiments, the unit in mg/mL was utilized and the conversion mistake only came when converting to mol% in order to define the ratio between the coating formulation components. The correct molecular weight of PEG-40 stearate is 2046.54 g/mol [2], [3], not 328.53 g/mol. On page 786, paragraph II-A, it should read "The coating was composed of 84.8 mol% DSPC (P6517, Sigma-Aldrich, Zwijndrecht, The Netherlands) or DPPC (850355, Avanti Polar Lipids, Alabaster, AL, USA); 8.2 mol% polyoxyethylene-40-stearate (PEG-40 stearate, P3440, Sigma-Aldrich); 5.9 mol% 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (DSPE-PEG(2000), 880125, Avanti Polar Lipids); and 1.1 mol% 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (DSPE-PEG(2000)-biotin, 880129, Avanti Polar Lipids)."
在上述文章[1]中，作者们遗憾地指出，在计算微泡包衣组合物的摩尔百分比时出现了一个错误。对于所有实验，使用的单位是mg/mL，只是在转换为摩尔百分比以确定包衣配方成分之间的比例时才出现了转换错误。聚乙二醇-40硬脂酸酯的正确分子量是2046.54 g/mol[2],[3]，而不是328.53 g/mol。在第786页，第二部分A段，应改为：“包衣由84.8摩尔%的二硬脂酰磷脂酰胆碱（P6517，西格玛奥德里奇公司，荷兰兹温德雷赫特）或二棕榈酰磷脂酰胆碱（850355，阿凡提极地脂质公司，美国阿拉巴马州阿拉巴斯特）；8.2摩尔%的聚氧乙烯-40-硬脂酸酯（聚乙二醇-40硬脂酸酯，P3440，西格玛奥德里奇公司）；5.9摩尔%的1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺-N-[羧基（聚乙二醇）-2000]（DSPE-PEG(2000)，880125，阿凡提极地脂质公司）；以及1.1摩尔%的1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺-N-[生物素基（聚乙二醇）-2000]（DSPE-PEG(2000)-生物素，880129，阿凡提极地脂质公司）组成。”
