Chair of Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Roma,Italy.
Curr Diabetes Rev. 2022;18(1):e030821192147. doi: 10.2174/1573399817666210309104740.
Diabetes mellitus (DM), one of the worldwide leading causes of death, is associated with a plethora of micro- and macro-vascular complications which should be carefully investigated and, in case, treated in order to improve quality of life and reduce the risk of premature mortality.
The study aimed to investigate and report current evidence with regard to the association between sexual dysfunction and diabetes.
A detailed analysis of current literature has been performed on PubMed and Scholar in order to retrieve the most relevant findings pertaining to the study topic.
Female and male sexual dysfunction often occurs in diabetes; while cardiovascular complications are clearly involved, psychosexological factors, endocrine complications, and endothelial dysfunction all contribute to the pathogenesis of sexual dysfunctions. Psychological symptoms are seldom investigated, yet they should not be overlooked by the clinician; in fact, an interplay between sexual dysfunctions and depressive symptoms has been reported, and beneficial effects in both conditions might be obtained by adequate psychological support. Sexual dysfunctions can also act as early biomarkers of cardiovascular disease, a phenomenon frequently reported in men, in which erectile dysfunction predicts the development of coronary artery disease. Additionally, drug therapies can act in both directions, with treatments for diabetes possibly improving male sexual function and exerting beneficial effects for cardiovascular health being reported for pro-erectile drugs.
Sexual dysfunctions often occur in men and women with diabetes. Investigating micro- and macro-vascular complications might not be enough to prevent the development or worsening of any sexual dysfunction; endocrine and psychological assessments are therefore needed to provide the best chances for adequate treatment.
糖尿病（DM）是全球主要死因之一，与多种微血管和大血管并发症相关。这些并发症应仔细检查并在必要时进行治疗，以改善生活质量并降低过早死亡的风险。
本研究旨在调查和报告糖尿病与性功能障碍之间的关联的现有证据。
通过在 PubMed 和 Scholar 上进行详细的文献分析，检索与研究主题相关的最相关发现。
女性和男性性功能障碍在糖尿病中经常发生；虽然心血管并发症明显涉及其中，但心理因素、内分泌并发症和内皮功能障碍都有助于性功能障碍的发病机制。心理症状很少被调查，但临床医生不应忽视它们；事实上，性功能障碍和抑郁症状之间存在相互作用，通过适当的心理支持可以在两种情况下获得有益的效果。性功能障碍也可以作为心血管疾病的早期生物标志物，这在男性中经常被报道，其中勃起功能障碍预测冠状动脉疾病的发展。此外，药物治疗可以双向作用，治疗糖尿病的药物可能改善男性性功能，并且已经报道了一些勃起药物对心血管健康有益的效果。
性功能障碍在患有糖尿病的男性和女性中经常发生。仅仅调查微血管和大血管并发症可能不足以预防任何性功能障碍的发生或恶化；因此，需要进行内分泌和心理评估，以提供充分治疗的最佳机会。
