Unit of Endocrinology and Diabetes, Department of Medicine, University Campus Bio-Medico di Roma, Rome, Italy.
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Diabetes Metab Res Rev. 2022 Feb;38(2):e3494. doi: 10.1002/dmrr.3494. Epub 2021 Sep 21.
Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common chronic diseases. The incidence and prevalence of DM have been increasing over the years. The complications of DM represent a serious health problem. The long-term complications include macroangiopathy, microangiopathy and neuropathy as well as sexual dysfunction (SD) in both men and women. Erectile dysfunction (ED) has been considered the most important SD in men with DM. The prevalence of ED is approximately 3.5-fold higher in men with DM than in those without DM. Common risk factors for the development of DM and its complications include sedentary lifestyle, overweight/obesity and increased caloric consumption. Although lifestyle changes may help improve sexual function, specific treatments are often needed. This study aims to review the definition and prevalence of ED in DM, the impact of DM complications and DM treatment on ED and, finally, the current and emerging therapies for ED in patients with DM.
糖尿病（DM）是一种以血糖升高为特征的慢性代谢性疾病，是最常见的慢性病之一。DM 的发病率和患病率多年来一直在上升。DM 的并发症是一个严重的健康问题。长期并发症包括大血管病变、微血管病变和神经病变以及男性和女性的性功能障碍（SD）。勃起功能障碍（ED）被认为是 DM 男性最重要的 SD。DM 男性的 ED 患病率大约比无 DM 男性高 3.5 倍。DM 及其并发症发展的常见危险因素包括久坐的生活方式、超重/肥胖和热量摄入增加。虽然生活方式的改变可能有助于改善性功能，但通常需要特定的治疗。本研究旨在回顾 DM 中 ED 的定义和流行率、DM 并发症和 DM 治疗对 ED 的影响，以及最后 DM 患者 ED 的当前和新兴治疗方法。
