Kleinman S, Fitzpatrick L, Secord K, Wilke D
American Red Cross Blood Services, Los Angeles-Orange Counties Region, CA.
Transfusion. 1988 May-Jun;28(3):280-2. doi: 10.1046/j.1537-2995.1988.28388219161.x.
We conducted anti-HIV testing on follow-up samples obtained at a mean interval of 20 weeks from 150 blood donors who had previously tested anti-HIV ELISA positive and Western blot atypical. Of 93 donors who demonstrated reactivity to HIV core protein p24, 4 progressed to positive Western blots. Most of the remaining donors showed a persistent p24 reactivity on Western blot and had no risk factors for HIV infection. Immunofluorescence testing of the initial sample from 93 donors could not definitively separate seroconverters from those with persistent p24 reactivity. Of 57 donors with p18 reactivity, none were positive on follow-up anti-HIV testing. Our findings suggest policies and strategies for notifying donors of atypical anti-HIV Western blot results.
我们对150名先前抗HIV ELISA检测呈阳性且免疫印迹不典型的献血者进行了随访样本的抗HIV检测，这些样本的平均采集间隔为20周。在93名对HIV核心蛋白p24呈反应性的献血者中，有4人免疫印迹转为阳性。其余大多数献血者免疫印迹显示p24持续呈反应性，且无HIV感染风险因素。对93名献血者的初始样本进行免疫荧光检测，无法明确区分血清转化者和p24反应持续者。在57名对p18呈反应性的献血者中，随访抗HIV检测均为阴性。我们的研究结果为向献血者通报不典型抗HIV免疫印迹结果提供了政策和策略。
