Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Department of Psychiatry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Clin Exp Optom. 2021 Sep;104(7):788-794. doi: 10.1080/08164622.2021.1878816. Epub 2021 Feb 25.
: Schizophrenia is a progressive disease. Analysis of retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia patients may help to explain the pathophysiology of the disease.: Both macular and optic nerve microvascular structures can be visualised with optical coherence tomography angiography. Few studies have evaluated retinal vessels in patients with schizophrenia. Some of these studies suggest that larger retinal venules are associated with the severity of psychotic symptoms.: This study evaluated retinal nerve fibre layer thickness and peripapillary vascular density by optical coherence tomography angiography in 22 eyes of 22 patients with schizophrenia and 26 eyes of 26 healthy control subjects. All peripapillary quadrants were evaluated with 4.5 × 4.5 mm images.: In the schizophrenia group, retinal nerve fibre layer thickness was significantly thinner and the mean peripapillary vascular density values were significantly lower in the temporal quadrant than in the control group (p < 0.05), but was similar in the peripapillary, superior, inferior, and nasal quadrants (p > 0.05). Peripapillary vascular density values and retinal nerve fibre layer thickness in schizophrenia patients were found to be lower in temporal quadrant compared to healthy eyes.: Evaluation of the retina with optical coherence tomography angiography may be useful in detecting and monitoring progressive neurodegeneration in patients with schizophrenia.
精神分裂症是一种进行性疾病。通过光相干断层扫描血管造影术分析精神分裂症患者的视网膜神经纤维层和视盘周围血管密度，可能有助于解释疾病的病理生理学。光相干断层扫描血管造影术可以观察到黄斑和视神经微血管结构。很少有研究评估精神分裂症患者的视网膜血管。其中一些研究表明，较大的视网膜静脉与精神病症状的严重程度有关。本研究通过光相干断层扫描血管造影术评估了 22 例精神分裂症患者的 22 只眼和 26 例健康对照者的 26 只眼的视网膜神经纤维层厚度和视盘周围血管密度。用 4.5×4.5mm 图像评估所有视盘周围象限。在精神分裂症组中，与对照组相比，颞侧象限的视网膜神经纤维层厚度明显变薄，平均视盘周围血管密度值明显降低（p<0.05），但视盘周围、上、下和鼻象限相似（p>0.05）。与健康眼相比，精神分裂症患者颞侧象限的视盘周围血管密度值和视网膜神经纤维层厚度较低。用光相干断层扫描血管造影术评估视网膜可能有助于检测和监测精神分裂症患者的进行性神经退行性变。
