Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Research Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Clin Exp Ophthalmol. 2020 Aug;48(6):775-782. doi: 10.1111/ceo.13783. Epub 2020 May 31.
To evaluate peripapillary vascular flow using optical coherence tomography angiography (angio-OCT) in patients with optic nerve head drusen (ONHD).
Angio-OCT allows non-invasive visualization and quantification peripapillary vascular flow.
Cross-sectional study.
Seventy-six eyes of 40 patients.
Between January 2018 and May 2019, consecutive patients with ONHD and healthy controls underwent a complete ocular assessment, including visual acuity testing, biomicroscopy, tonometry, funduscopy, automated perimetry, retinography and autofluorescence, spectral-domain OCT and peripapillary angio-OCT.
Peripapillary vascular flow, vascular density, retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) thicknesses.
We included 23 patients with ONHD (42 eyes, 32 with visible drusen; mean age 50.96 years, 12 men) and 17 control patients (34 eyes; mean age 47.12 years, 7 men), without significant differences in age or sex. Vascular flow and density were significantly lower in patients with ONHD (0.409% and 40.18%, respectively) than in normal eyes (0.438% and 43.30%, respectively) (P = .006 and P < .001). RNFL and GCL thicknesses were significantly lower in patients with ONHD (81.81 and 77.43 μm, respectively) than in controls (91.38 and 81.97 μm, respectively) (P = .001 and P = .032). We obtained high correlation indexes between RNFL and GCL and vascular flow and density (RNFL = 0.702 and 0.744, respectively, and GCL = 0.808 and 0.857, respectively).
Angio-OCT demonstrated significant reductions in peripapillary vascular flow and vascular density in patients with ONHD, with strong correlations with RNFL and GCL thicknesses.
使用光学相干断层扫描血管造影（angio-OCT）评估视神经乳头玻璃膜疣（ONHD）患者的视乳头周围血管血流。
angio-OCT 允许对视乳头周围血管血流进行非侵入性可视化和量化。
横断面研究。
40 名患者的 76 只眼。
2018 年 1 月至 2019 年 5 月，连续就诊的视神经乳头玻璃膜疣患者和健康对照者接受了全面的眼部评估，包括视力测试、生物显微镜检查、眼压测量、眼底检查、自动视野检查、视网膜摄影和自发荧光、谱域 OCT 和视乳头周围血管造影。
视乳头周围血管血流、血管密度、视网膜神经纤维层（RNFL）和节细胞层（GCL）厚度。
我们纳入了 23 名视神经乳头玻璃膜疣患者（42 只眼，其中 32 只眼可见玻璃膜疣；平均年龄 50.96 岁，12 名男性）和 17 名正常对照者（34 只眼；平均年龄 47.12 岁，7 名男性），两组在年龄和性别上无显著差异。视神经乳头玻璃膜疣患者的血管血流和密度明显低于正常眼（分别为 0.409%和 40.18%）（P=0.006 和 P<0.001）。视神经乳头玻璃膜疣患者的 RNFL 和 GCL 厚度明显低于对照组（分别为 81.81 和 77.43μm）（P=0.001 和 P=0.032）。我们获得了 RNFL 和 GCL 与血管血流和密度之间的高相关指数（RNFL=0.702 和 0.744，分别；GCL=0.808 和 0.857，分别）。
angio-OCT 显示视神经乳头玻璃膜疣患者视乳头周围血管血流明显减少，与 RNFL 和 GCL 厚度有很强的相关性。
