Department of Ophthalmology, Aerospace Medical Center, Republic of Korea Air Force, Cheongju, South Korea.
Department of Anesthesiology and Pain Medicine, Seoul Women's Hospital, Bucheon, South Korea.
Pain Med. 2021 Nov 26;22(11):2525-2532. doi: 10.1093/pm/pnab085.
Recently, several researchers reported an association between osteoarthritis and dry eye syndrome (DES) and suggested that they may be related to central sensitization. We investigated the association between DES, osteoarthritis pain, and radiographic severity.
A nationwide, cross-sectional study.
The Fifth Korean National Health and Nutrition Examination Survey.
8,664 participants in this survey.
Osteoarthritis-associated radiographic changes were evaluated by trained radiologists. Multivariable logistic regression was performed to examine the relationship between osteoarthritis pain, radiographic severity, and DES. The odds ratios (ORs) of DES were analyzed in accordance with the presence of osteoarthritis-associated factors.
Radiographic knee osteoarthritis was significantly associated with lower ORs for DES (OR = 0.80, P = 0.046, for diagnosed/self-reported DES; OR = 0.84, P = 0.034, for symptoms of DES). Knee pain or stiffness was significantly associated with higher ORs for DES (OR = 1.28, P = 0.020, for diagnosed/self-reported DES; OR = 1.29, P = 0.003, for symptoms of DES). In patients with symptomatic osteoarthritis, DES was not significantly associated with radiographic severity of osteoarthritis. In patients with nonsymptomatic radiographic osteoarthritis, DES was inversely related with radiographic severity (Ptrend = 0.012 for diagnosed/self-reported DES; Ptrend < 0.001 for symptoms of DES).
Radiographic osteoarthritis showed a significant association with decreased DES. Patients with less pain and severe radiographic OA were more likely to have less DES. Our results suggest that the degree of pain caused by osteoarthritis and central sensitization may be closely associated with DES.
最近，一些研究人员报告了骨关节炎和干眼症（DES）之间的关联，并提出它们可能与中枢敏化有关。我们调查了 DES、骨关节炎疼痛和放射学严重程度之间的关联。
一项全国性的横断面研究。
第五次韩国国家健康和营养检查调查。
该调查的 8664 名参与者。
由经过培训的放射科医生评估与骨关节炎相关的放射学改变。使用多变量逻辑回归来检查骨关节炎疼痛、放射学严重程度和 DES 之间的关系。根据存在与骨关节炎相关的因素分析 DES 的比值比（OR）。
放射学膝关节骨关节炎与 DES 的较低 OR 显著相关（诊断/自我报告 DES 的 OR = 0.80，P = 0.046；DES 症状的 OR = 0.84，P = 0.034）。膝关节疼痛或僵硬与 DES 的更高 OR 显著相关（诊断/自我报告 DES 的 OR = 1.28，P = 0.020；DES 症状的 OR = 1.29，P = 0.003）。在有症状性骨关节炎的患者中，DES 与骨关节炎的放射学严重程度无显著相关性。在无症状性放射学骨关节炎的患者中，DES 与放射学严重程度呈负相关（诊断/自我报告 DES 的 Ptrend = 0.012；DES 症状的 Ptrend < 0.001）。
放射学骨关节炎与 DES 显著相关。疼痛程度较低和放射学 OA 严重程度较高的患者更有可能出现较少的 DES。我们的结果表明，骨关节炎引起的疼痛程度和中枢敏化可能与 DES 密切相关。
