Departments of Physical Medicine and Rehabilitation, Neurology, and Psychology, University of Alabama at Birmingham, Birmingham, Alabama.
Semin Neurol. 2021 Apr;41(2):177-188. doi: 10.1055/s-0041-1725139. Epub 2021 Mar 9.
Multiple sclerosis (MS) is a progressive neurological illness whose typically young adult onset results in a nearly entire lifetime of worsening disability. But despite being an unrelenting neurodegenerative disease, numerous clinical trials over the past 40 years for MS have vigorously attempted to improve or at least stabilize declining physical function. Although the vast majority of the studies assessed training effects only within controlled laboratory or clinic settings, in recent years a growing interest has emerged to test whether newer therapies can instead benefit real-life activities in the community. Nonetheless, comparatively little attention has been paid to whether the training gains can be retained for meaningful periods. This review discusses the comparative success of various physical training methods to benefit within-community activities in MS, and whether the gains can be retained long afterward. This review will suggest future research directions toward establishing efficacious treatments that can allow persons with MS to reclaim their physical abilities and maximize functionality for meaningful periods.
多发性硬化症（MS）是一种进行性的神经疾病，其典型的发病年龄为成年早期，这导致患者在几乎一生的时间里残疾程度不断恶化。但尽管多发性硬化症是一种无法治愈的神经退行性疾病，过去 40 多年来，仍有许多临床试验积极尝试改善或至少稳定身体机能的下降。尽管绝大多数研究仅在受控的实验室或临床环境中评估了训练效果，但近年来，人们越来越感兴趣地测试新疗法是否可以替代社区中的实际活动带来益处。尽管如此，人们相对较少关注训练效果是否可以长期保持。这篇综述讨论了各种身体训练方法在多发性硬化症的社区内活动中的相对成功，以及这些效果是否可以长期保持。这篇综述将为未来的研究方向提供建议，旨在建立有效的治疗方法，使多发性硬化症患者能够重新获得身体能力，并在较长时间内最大限度地发挥功能。
