He Yini, Li Kaixin, Li Jin, Wang Jiaojian, Cheng Nanhua, Xiao Jing, Jiang Tianzi
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin 150080, China.
Neuroscience. 2021 May 1;461:36-43. doi: 10.1016/j.neuroscience.2021.02.031. Epub 2021 Mar 7.
As a textbook manifestation of an aggressive attitude, hostility can pose a serious threat to both an individual's life and the security of society at large. Past evidence suggests that some anxiety-related traits may be more prone to giving rise to hostility. However, many aspects of hostility, such as, determining the susceptible temperament for hostility, the neural basis of hostility, and the underlying mechanisms through which having a susceptible temperament generates hostility in a healthy brain, remain unclear. In this study, we sought to delve into these questions by assessing temperament and brain white matter integrity using self-report questionnaires and diffusion tensor imaging in a sizable sample of healthy adults (n = 357). First, we investigated the relationship between hostility and the four temperaments of the Cloninger model. Then, we investigated which white matter tracts were significantly correlated with hostility using a whole-brain analysis. Finally, we used a mediation analysis to explore the tripartite relationship between vulnerability temperament, the fractional anisotropy (FA) value of the white matter, and hostility. Our results suggest that a harm avoidance temperament may be susceptible to hostility and that the cingulum may be a key white matter region responsible for hostility. Based on these results, we developed a temperament-brain-attitude pathway showing how harm avoidance temperament could affect the brain and ultimately lead to hostility.
作为攻击性行为的一种典型表现，敌意可能对个人生活以及整个社会的安全构成严重威胁。过去的证据表明，一些与焦虑相关的特质可能更容易引发敌意。然而，敌意的许多方面，比如确定易产生敌意的气质类型、敌意的神经基础，以及在健康大脑中易感性气质引发敌意的潜在机制，仍然不清楚。在本研究中，我们试图通过使用自我报告问卷和扩散张量成像技术，对大量健康成年人样本（n = 357）进行气质和脑白质完整性评估，来深入探究这些问题。首先，我们研究了敌意与克隆宁格模型的四种气质类型之间的关系。然后，我们通过全脑分析研究了哪些白质束与敌意显著相关。最后，我们使用中介分析来探讨易感性气质、白质分数各向异性（FA）值和敌意之间的三方关系。我们的结果表明，回避伤害气质可能易引发敌意，扣带回可能是与敌意相关的关键脑白质区域。基于这些结果，我们构建了一个气质-脑-态度通路，展示了回避伤害气质如何影响大脑并最终导致敌意。
