Rozanov V A, Karpovich G A, Sergeeva O N, Kopelevich V M, Gunar V I
Vopr Med Khim. 1988 Jan-Feb;34(1):29-33.
Effect of repeated administrations of gamma-amino butyric acid (GABA) at doses corresponding to those which are used in clinical medicine, on the state of GABA-shunt and intensity of alpha-ketoglutarate dehydrogenase and aminotransferase reactions as well as on the level of GABA and glutamate was studied in cerebellum, cortex and trunkus cerebri of rat brain. Administration of GABA (5 injections at a dose of 5 mg/kg) caused distinct alterations in central nervous system, which involved activation of GABA-transaminase, utilizing GABA, and inactivation of glutamate decarboxylase, producing the amine, as well as a decrease of GABA and glutamate levels and an increase in alpha-ketoglutarate utilization and activation of aminotransferase reactions. These alterations were especially distinct in cerebellum, where initial high intensity of GABA shunt functioning and minimal level of GABA were observed. The alterations observed suggest the existence of pronounced stimulating effect of GABA, even at low doses, on reactions of energy metabolism in brain.
研究了以临床医学所用剂量重复给予γ-氨基丁酸（GABA）对大鼠脑小脑、皮质和脑干中GABA分流状态、α-酮戊二酸脱氢酶和转氨酶反应强度以及GABA和谷氨酸水平的影响。给予GABA（5次注射，剂量为5mg/kg）导致中枢神经系统出现明显变化，包括利用GABA的GABA转氨酶激活、产生该胺的谷氨酸脱羧酶失活，以及GABA和谷氨酸水平降低、α-酮戊二酸利用增加和转氨酶反应激活。这些变化在小脑尤为明显，在小脑中观察到GABA分流功能最初的高强度和GABA的最低水平。观察到的这些变化表明，即使在低剂量下，GABA对脑能量代谢反应也存在明显的刺激作用。
