Nie Luting, Wei Dandan, Liu Pengling, Zhang Li, Fan Keliang, Song Yu, Wang Mian, Wang Lulu, Xu Qingqing, Wang Juan, Liu Xiaotian, Li Linlin, Mao Zhenxing, Huang Hui, Wang Chongjian, Huo Wenqian
Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
J Inflamm Res. 2021 Mar 4;14:633-644. doi: 10.2147/JIR.S293882. eCollection 2021.
Studies of progesterone with obesity have been lacking, and no prior studies have investigated progesterone and C-reactive protein in rural natural populations. This study aimed to investigate the association of serum progesterone with obesity based on anthropometric parameters in Henan Rural Cohort, then further to explore the potential role of C-reactive protein in this association.
A total of 4687 participants (2474 men and 2213 postmenopausal women) from the Henan Rural Cohort study were included. Logistic regression analysis, linear regression analysis, and restricted cubic splines were performed to estimate the relationships between progesterone, C-reactive protein, obesity, and obesity-related parameters. Mediation analysis was carried out to assess the intermediary role of C-reactive protein played in the association between progesterone and obesity.
After controlling for confounders, the odds ratios of obesity no matter how obesity was defined was associated with progesterone ( trend <0.05). Moreover, progesterone was related to obesity-related parameters. Also, C-reactive protein increased with the elevation of progesterone, and C-reactive protein was associated with obesity no matter how obesity was defined ( trend <0.001). Mediation analysis indicated that hsCRP had the mediating effects on the obesity, and the proportion of the effects were 15.35% and full mediating effect (defined by body mass index), 15.46% and 12.24% (defined by waist circumference), 19.14% and 12.12% (defined by waist-to-hip ratio), 23.81% and 15.09% (defined by waist-to-height ratio) for men and postmenopausal women, relatively.
In the Chinese rural men and postmenopausal women population, progesterone and C-reactive protein are related to obesity. We firstly found C-reactive protein partly mediates the effect of progesterone on obesity, indicating that systemic inflammation played a critical role in the association.
关于孕酮与肥胖的研究一直缺乏，且此前没有研究在农村自然人群中调查过孕酮与C反应蛋白的关系。本研究旨在基于河南农村队列的人体测量参数，调查血清孕酮与肥胖的关联，进而探讨C反应蛋白在这种关联中的潜在作用。
纳入了河南农村队列研究中的4687名参与者（2474名男性和2213名绝经后女性）。进行了逻辑回归分析、线性回归分析和受限立方样条分析，以估计孕酮、C反应蛋白、肥胖及肥胖相关参数之间的关系。进行中介分析以评估C反应蛋白在孕酮与肥胖关联中所起的中介作用。
在控制混杂因素后，无论肥胖如何定义，肥胖的比值比均与孕酮相关（趋势<0.05）。此外，孕酮与肥胖相关参数有关。而且，C反应蛋白随孕酮升高而增加，无论肥胖如何定义，C反应蛋白均与肥胖相关（趋势<0.001）。中介分析表明，hsCRP对肥胖有中介作用，男性和绝经后女性的中介效应比例分别为：按体重指数定义为15.35%且为完全中介效应，按腰围定义为15.46%和12.24%，按腰臀比定义为19.14%和12.12%，按腰高比定义为23.81%和15.09%。
在中国农村男性和绝经后女性人群中，孕酮和C反应蛋白与肥胖有关。我们首次发现C反应蛋白部分介导了孕酮对肥胖的影响，表明全身炎症在这种关联中起关键作用。
