Sadahiro Taketaro
Department of Cardiology, Faculty of Medicine, University of Tsukuba Tsukuba Japan.
Circ Rep. 2019 Nov 12;1(12):564-567. doi: 10.1253/circrep.CR-19-0104.
Cardiovascular disease is the leading cause of death and disability worldwide. Despite advances in cardiovascular therapy, mortality in heart disease still remains high. Direct cardiac reprogramming is a promising approach for cardiac tissue repair involving in situ generation of new cardiomyocytes from endogenous cardiac fibroblasts. Although, initially, the reprogramming efficiency was low, several developments in reprogramming methods have improved the in vitro cardiac reprogramming efficiency. Subsequently, in vivo cardiac reprogramming has demonstrated improvement in cardiac function and fibrosis after myocardial infarction. Here, we review recent progress in cardiac reprogramming as a new technology for cardiac regeneration.
心血管疾病是全球范围内导致死亡和残疾的主要原因。尽管心血管治疗取得了进展，但心脏病的死亡率仍然很高。直接心脏重编程是一种有前景的心脏组织修复方法，涉及从内源性心脏成纤维细胞原位生成新的心肌细胞。虽然最初重编程效率较低，但重编程方法的一些进展提高了体外心脏重编程效率。随后，体内心脏重编程已证明在心肌梗死后心脏功能和纤维化方面有所改善。在此，我们综述心脏重编程作为心脏再生新技术的最新进展。
