Amity Food & Agriculture Foundation, Amity University Uttar Pradesh, Sector 125, Noida 201313, India.
Department of Crop, Soil & Environmental Sciences, University of Arkansas, Fayetteville, AR, USA.
J Exp Bot. 2021 Sep 2;72(17):6042-6065. doi: 10.1093/jxb/erab079.
The Snf1-related protein kinase 1 (SnRK1) is the plant homolog of the heterotrimeric AMP-activated protein kinase/sucrose non-fermenting 1 (AMPK/Snf1), which works as a major regulator of growth under nutrient-limiting conditions in eukaryotes. Along with its conserved role as a master regulator of sugar starvation responses, SnRK1 is involved in controlling the developmental plasticity and resilience under diverse environmental conditions in plants. In this review, through mining and analyzing the interactome and phosphoproteome data of SnRK1, we are highlighting its role in fundamental cellular processes such as gene regulation, protein synthesis, primary metabolism, protein trafficking, nutrient homeostasis, and autophagy. Along with the well-characterized molecular interaction in SnRK1 signaling, our analysis highlights several unchartered regions of SnRK1 signaling in plants such as its possible communication with chromatin remodelers, histone modifiers, and inositol phosphate signaling. We also discuss potential reciprocal interactions of SnRK1 signaling with other signaling pathways and cellular processes, which could be involved in maintaining flexibility and homeostasis under different environmental conditions. Overall, this review provides a comprehensive overview of the SnRK1 signaling network in plants and suggests many novel directions for future research.
Snf1 相关蛋白激酶 1（SnRK1）是真核生物中三聚体 AMP 激活蛋白激酶/蔗糖非发酵 1（AMPK/Snf1）的植物同源物，作为营养限制条件下生长的主要调节剂。除了作为糖饥饿反应的主要调节剂的保守作用外，SnRK1 还参与控制植物在各种环境条件下的发育可塑性和弹性。在这篇综述中，通过挖掘和分析 SnRK1 的互作组和磷酸化蛋白质组数据，我们强调了它在基因调控、蛋白质合成、初级代谢、蛋白质运输、养分稳态和自噬等基本细胞过程中的作用。除了 SnRK1 信号传导中已很好表征的分子相互作用外，我们的分析还突出了 SnRK1 信号在植物中几个未被探索的区域，例如它与染色质重塑剂、组蛋白修饰剂和肌醇磷酸盐信号之间可能的通信。我们还讨论了 SnRK1 信号与其他信号通路和细胞过程之间潜在的相互作用，这可能涉及在不同环境条件下维持灵活性和内稳态。总的来说，这篇综述提供了植物中 SnRK1 信号网络的全面概述，并为未来的研究提出了许多新的方向。
