Inoue K, Ogawa M, Horikoshi N, Mukaiyama T, Itoh Y, Imajoh K, Ozeki H, Nagamine D, Shinagawa K
Dept. of Clinical Oncology, Cancer Institute Hospital, Tokyo, Japan.
Gan To Kagaku Ryoho. 1988 May;15(5):1771-6.
SM-5887, a new totally synthetic anthracycline derivative, was studied in a phase I setting. Twenty-nine evaluable courses of treatment were conducted in groups at doses increasing from 10 to 130 mg/m2. At 130 mg/m2 the median lowest WBC count was 0.7 x 10(3)/mm3 (range 0.3-1.8) and the median lowest platelet count was 57 x 10(3)/mm3 (range 4-176). Nonhematological side effects were mild gastrointestinal symptoms and hair loss. The recommended dose and schedule for a phase II setting is 100 mg/m2 every 3 weeks.
