O'Mullane J E, Davison C J, Petrak K, Tomlinson E
Advanced Drug Delivery Research Unit, Ciba-Geigy Pharmaceuticals, Horsham, West Sussex, UK.
Biomaterials. 1988 Mar;9(2):203-4. doi: 10.1016/0142-9612(88)90124-x.
We have measured the isothermal adsorption of 125I-fibrinogen on to polystyrene latex (PSL), which was prepared without surfactants, and on to PSL with an adsorbed coat of poloxamer 338 (an A-B-A block copolymer where A is poly(oxyethylene) and B is poly(oxypropylene]. The plateau adsorption of fibrinogen, at 310 K, was significantly lower on to latex coated with poloxamer 338. Previous studies have shown that poloxamer 338-coated PSL is cleared less avidly than uncoated PSL by cells of the mononuclear phagocytic system (MPS). Our findings are quantitative evidence in support of the theory that the uptake of colloids by the MPS can be related to the interfacial adsorption of opsonic proteins.
