应用抗眼镜蛇毒马免疫 Fab' 片段抗体治疗蛇咬伤。
Use of Crotalidae equine immune F(ab') antivenom for treatment of an envenomation.
机构信息
Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
出版信息
Clin Toxicol (Phila). 2021 Nov;59(11):1023-1026. doi: 10.1080/15563650.2021.1892718. Epub 2021 Mar 11.
INTRODUCTION
Anavip (F(ab')AV) is a lyophilized F(ab') immunoglobulin fragment derived from horses immunized with venom from and . It was approved by the FDA in 2015 for treatment of North American rattlesnake envenomation but not for envenomation. Published data regarding the efficacy and safety of Anavip in treating envenomations is limited. We present a case of a patient treated with Anavip after confirmed envenomation.
CASE DETAILS
A 77 year-old man was bitten on his fifth finger by a captive . He was taken to a local emergency department where he received a 10 vial initial dose of F(ab')AV for pain and swelling and was transferred. At the receiving facility, his pain had improved and his swelling had not progressed. Over the next 30 h, his platelets declined to 132,000/mm and he received an additional 4 vials of F(ab')AV. The remainder of his course was unremarkable with complete recovery by 3 months.
DISCUSSION
This case provides an additional published datapoint on the use of this F(ab')AV in the treatment of envenomation by .
简介
Anavip（F(ab')AV）是一种冻干的 F(ab')免疫球蛋白片段，源自用 和 毒液免疫的马。它于 2015 年获得 FDA 批准，用于治疗北美响尾蛇咬伤，但不用于治疗 咬伤。关于 Anavip 治疗 咬伤的疗效和安全性的已发表数据有限。我们报告了一例经证实的 咬伤患者接受 Anavip 治疗的病例。
病例详情
一名 77 岁男性被一只圈养的 咬伤了第五根手指。他被送往当地急诊室，在那里接受了 10 瓶初始剂量的 F(ab')AV 以缓解疼痛和肿胀，随后被转院。在接收机构，他的疼痛有所改善，肿胀没有进展。在接下来的 30 小时内，他的血小板降至 132,000/mm，并额外接受了 4 瓶 F(ab')AV。他的其余病程无明显异常，3 个月后完全康复。
讨论
本病例提供了另一个关于该 F(ab')AV 在治疗 咬伤方面的使用的已发表数据点。
Zotero 插件