Devor M, Dubner R
Department of Zoology, Hebrew University of Jerusalem, Israel.
Brain Res. 1988 Apr 19;446(2):396-400. doi: 10.1016/0006-8993(88)90901-8.
We have investigated the effect of a prolonged, low-frequency impulse barrage on the spontaneous afferent discharge that originates in experimental nerve-end neuromas in the rat sciatic nerve. Centrifugal activity in afferent A-fibers did not affect electrogenesis in the neuroma. When C-fibers were recruited, however, over half of the axons tested were either suppressed or excited. We suggest that these effects resulted from the stimulation-evoked release of neuroactive peptides or related substances from the cut ends of afferent C-fibers.
