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属真菌产生的次生代谢产物的风险评估。

Risk assessment of secondary metabolites produced by fungi in the genus .

机构信息

Department of Plant Agriculture, University of Guelph, Guelph, Ontario, Canada.

Agriculture and Agri-Food Canada, Saskatoon Research Centre, Saskatoon, Saskatchewan. Canada.

出版信息

Can J Microbiol. 2021 Jun;67(6):445-450. doi: 10.1139/cjm-2020-0351. Epub 2021 Mar 11.

DOI:10.1139/cjm-2020-0351
PMID:33705203
Abstract

The fungal genus (phylum Ascomycota, teleomorph ) includes plant pathogenic, endophytic, and saprophytic species with worldwide distributions. spp. produce prodigious numbers of airborne spores, so are a human health concern as allergens. Some species also produce secondary metabolites, such as glucosides, ferric chelates, aromatic polyketides, and others, that function as toxins that damage plants and other fungal species. Some of these compounds also exhibit a low level of mammalian toxicity. The high production of airborne spores by this genus can result in a high incidence of human exposure. Concern about toxin production appears to be the reason that , which is a pathogen of several vegetable crops, was classified in Canada as a potential risk of harm to humans for many years. A detailed assessment of the risk of exposure was provided to the relevant regulatory body, the Public Health Agency of Canada, which then determined that spp. in nature or under laboratory conditions posed little to no risk to humans or animals, and the species was re-assigned as a basic (level 1) risk agent.

摘要

(子囊菌门,有性型)真菌属包括具有世界分布的植物病原性、内生性和腐生性种。属产生大量的空气传播孢子,因此作为过敏原对人类健康构成关注。一些物种还产生次级代谢产物,如糖苷、铁螯合物、芳香聚酮和其他物质,它们作为毒素损害植物和其他真菌物种。这些化合物中的一些也表现出低水平的哺乳动物毒性。该属空气中孢子的大量产生可导致人类暴露的高发生率。对毒素产生的关注似乎是多年来将 (几种蔬菜作物的病原体)归类为对人类潜在危害风险的原因。向相关监管机构加拿大公共卫生局提供了对接触风险的详细评估,然后确定在自然界或实验室条件下的 属种对人类或动物几乎没有风险,该物种被重新归类为基本(一级)风险剂。

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