Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Department of Physical Medicine and Rehabilitation, Christian Medical College, Vellore, India.
J Spinal Cord Med. 2022 Nov;45(6):857-864. doi: 10.1080/10790268.2021.1888021. Epub 2021 Mar 11.
To study body composition, measures of insulin resistance and dyslipidemia in Indian men with paraplegia as compared to age and body mass index (BMI) matched able-bodied men.
Cross sectional study.
Departments of Physical Medicine and Rehabilitation and Endocrinology.
Males aged 18-45 years with chronic traumatic paraplegia versus age and BMI-matched able-bodied men.
None.
Measures of body composition such as total body fat, lean mass, regional adiposity using dual energy x-ray absorptiometry (DXA), metabolic profile and insulin resistance.
Subjects with paraplegia ( = 43), compared to controls ( = 36), had higher %Fat mass (FM) (25.5 (21.2-28.9) vs 20.2 (15.9-22.2); P < 0.01), lower trunk to leg ratio (0.66 (0.51-0.73) vs 0.87 (0.72-0.94); P < 0.01), lower lean mass index (14.38 (2.57) vs 17.80 (2.34); P < 0.01) and lower appendicular lean mass index (5.81 ± 1.26 vs 8.17 ± 1.12; P < 0.01). Fasting blood glucose (mg/dl) was higher (89.0(81.5-96.5) vs 80.0 (74.5-88.2); P < 0.01), Homeostasis model assessment of insulin resistance was higher (1.33 (1.03-2.12) vs 0.94 (0.52-1.78); P = 0.02), Quantitative insulin sensitivity check index (QUICKI) was lower (0.36 ± 0.04 vs 0.38 ± 0.05; P = 0.02) and HDL-C was lower (33.00 (30.00-42.75) vs 38.50 (33.00-43.25); P < 0.02) in cases compared to controls. QUICKI correlated positively with HDL-C and negatively with %FM, estimated VAT volume and TG. Trunk to leg ratio correlated positively with TG even after controlling for %FM.
Men with chronic paraplegia had lower lean mass, higher total and regional fat mass, increased insulin resistance and low HDL-C when compared with BMI-matched able-bodied controls. Both total and regional adiposity correlated with poor metabolic profile.
与年龄和体重指数（BMI）匹配的健康对照组相比，研究印度截瘫男性的身体成分、胰岛素抵抗和血脂异常。
横断面研究。
物理医学和康复科以及内分泌科。
18-45 岁慢性创伤性截瘫男性与年龄和 BMI 匹配的健康对照组男性。
无。
使用双能 X 线吸收法（DXA）评估身体成分，如全身脂肪量、瘦体重、局部肥胖程度，代谢特征和胰岛素抵抗。
与对照组（n=36）相比，截瘫组（n=43）的体脂肪百分比（FM）更高（25.5（21.2-28.9）比 20.2（15.9-22.2）；P<0.01），躯干-下肢比值更低（0.66（0.51-0.73）比 0.87（0.72-0.94）；P<0.01），瘦体重指数更低（14.38（2.57）比 17.80（2.34）；P<0.01），四肢瘦体重指数更低（5.81±1.26 比 8.17±1.12；P<0.01）。空腹血糖（mg/dl）更高（89.0（81.5-96.5）比 80.0（74.5-88.2）；P<0.01），胰岛素抵抗的稳态模型评估（HOMA-IR）更高（1.33（1.03-2.12）比 0.94（0.52-1.78）；P=0.02），定量胰岛素敏感指数（QUICKI）更低（0.36±0.04 比 0.38±0.05；P=0.02），高密度脂蛋白胆固醇（HDL-C）更低（33.00（30.00-42.75）比 38.50（33.00-43.25）；P<0.02）。与对照组相比，病例组的 QUICKI 与 HDL-C 呈正相关，与 %FM、估计的 VAT 体积和 TG 呈负相关。躯干-下肢比值与 TG 呈正相关，即使在控制了 %FM 之后也是如此。
与 BMI 匹配的健康对照组相比，慢性截瘫男性的瘦体重较低，全身和局部脂肪量较高，胰岛素抵抗和 HDL-C 水平较低。全身和局部肥胖与代谢特征不良有关。
