间充质干细胞在颞下颌关节相关结构再生中的疗效：系统评价。
The efficacy of mesenchymal stem cells in regenerating structures associated with the temporomandibular joint: A systematic review.
机构信息
Institute of Education and Research - IEP, Sírio Libanês Hospital, São Paulo, Brazil.
Maxillofacial Education, Aracaju, Sergipe, Brazil.
出版信息
Arch Oral Biol. 2021 May;125:105104. doi: 10.1016/j.archoralbio.2021.105104. Epub 2021 Mar 6.
OBJECTIVES
The objective of this systematic review is to evaluate the role of mesenchymal stem cells in the regenerative treatment of temporomandibular joint resorption.
DESIGN
Search strategies were performed in the following databases: PubMed/MEDLINE, EMBASE, Cochrane Collaboration Library, and Web of Science. Two independent reviewers selected the included articles using a two-phase process based on the eligibility criteria. The reviewers independently collected the required information from the included articles. The methodological quality of the selected studies was assessed individually.
RESULT
In accordance with the inclusion and exclusion criteria, 703 studies were found and 8 articles were included. Thus, six studies using animal models and two human studies were included in this systematic review.
CONCLUSION
Based on the data of our systematic review, the use of mesenchymal stem cells is a promising method for the repair and regeneration of temporomandibular joint components.
目的
本系统评价旨在评估间充质干细胞在颞下颌关节吸收再生治疗中的作用。
设计
在以下数据库中进行了搜索策略：PubMed/MEDLINE、EMBASE、Cochrane 协作图书馆和 Web of Science。两名独立评审员使用基于入选标准的两阶段过程选择了纳入的文章。评审员从纳入的文章中独立收集了所需的信息。单独评估了选定研究的方法学质量。
结果
根据纳入和排除标准，共发现 703 篇研究，纳入 8 篇文章。因此，本系统评价纳入了 6 项使用动物模型的研究和 2 项人体研究。
结论
根据我们的系统评价数据，间充质干细胞的使用是修复和再生颞下颌关节成分的一种很有前途的方法。
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