Zinn K, McAllister L, Goodman C S
Department of Biological Sciences, Stanford University, California 94305.
Cell. 1988 May 20;53(4):577-87. doi: 10.1016/0092-8674(88)90574-0.
The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Drosophila fasciclin I homolog. In both species, fasciclin I appears to be an extrinsic membrane protein with a signal sequence but no transmembrane region; the protein comprises four homologous domains of approximately 150 amino acids each. Antibodies against Drosophila fasciclin I reveal that it is expressed on the surface of a subset of commissural axon pathways in the embryonic central nervous system and on all sensory axon pathways in the peripheral nervous system. This pattern of expression is similar to that in grasshopper.
成束蛋白I、II和III糖蛋白在昆虫胚胎的不同轴突束（神经束）亚群上表达，因此是参与生长锥导向的表面识别分子的候选者。在此，我们展示了蝗虫成束蛋白I的序列以及果蝇成束蛋白I同源物的鉴定和序列。在这两个物种中，成束蛋白I似乎是一种具有信号序列但没有跨膜区域的外在膜蛋白；该蛋白由四个同源结构域组成，每个结构域约含150个氨基酸。针对果蝇成束蛋白I的抗体显示，它在胚胎中枢神经系统中连合轴突通路的一个亚群的表面以及外周神经系统中所有感觉轴突通路上表达。这种表达模式与蝗虫中的相似。
