Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 128 00, Prague 2, Czech Republic.
Department of Cellular Pathology, Barts Health NHS Trust, Queen Mary University of London, London, UK.
Diagn Pathol. 2021 Mar 11;16(1):20. doi: 10.1186/s13000-021-01079-2.
Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, with a focus on the possibilities of the differential diagnosis at the macroscopic, microscopic and immunohistochemical level.
The three main aspects of mucinous ovarian tumors are described in detail, including the comparison of the available diagnostic algorithms based on the evaluation of mostly macroscopic features, characterization of the spectrum of microscopic features, and a detailed analysis of the immunophenotype comparing 20 antibodies with the assessment of their statistical significance for differential diagnosis purposes. Specific features, including Krukenberg tumor and pseudomyxoma peritonei, are also discussed.
Despite the growing knowledge of the macroscopic and microscopic features of ovarian mucinous tumors and the availability of a wide range of immunohistochemical antibodies useful in this setting, there still remains a group of tumors which cannot be precisely classified without close clinical-pathological cooperation.
原发性和转移性卵巢黏液性肿瘤的鉴别通常较为困难，特别是对于来源于胃肠道、胰腺和胆道系统的肿瘤。本文旨在概述这一问题，并重点探讨在大体、镜下和免疫组化水平上鉴别诊断的可能性。
本文详细描述了三种主要的卵巢黏液性肿瘤，包括基于评估主要大体特征的现有诊断算法的比较、微观特征谱的特征化，以及对 20 种抗体的免疫表型进行详细分析，并评估其在鉴别诊断中的统计学意义。此外，还讨论了特定特征，包括克鲁肯贝格肿瘤和腹膜假黏液瘤。
尽管对卵巢黏液性肿瘤的大体和镜下特征的认识不断增加，并且在这种情况下有广泛的免疫组化抗体可供使用，但如果没有密切的临床病理合作，仍有一组肿瘤无法进行准确分类。
