毛细支气管炎与 SARS-CoV-2。
Bronchiolitis and SARS-CoV-2.
机构信息
Pediatric Unit, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milano, Lombardia, Italy.
Department of Clinical Science and Community Health, Università degli Studi di Milano, Milan, Lombardia, Italy.
出版信息
Arch Dis Child. 2021 Oct;106(10):999-1001. doi: 10.1136/archdischild-2020-321108. Epub 2021 Mar 11.
BACKGROUND
It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020.
METHODS
We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019.
RESULTS
The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2.
CONCLUSIONS
This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.
背景
有人推测，2020 年 2 月之前，SARS-CoV-2 已在西方国家广泛传播。
方法
我们通过分析 2019 年 11 月至 2020 年 2 月期间米兰 Ospedale Maggiore 医院收治的患有毛细支气管炎或非传染性疾病的婴儿的鼻拭子来评估这一假设。
结果
在 218 名患有毛细支气管炎的婴儿（95 名女性，中位年龄 4.9 个月）和 49 名患有非传染性疾病的婴儿（22 名女性，中位年龄 5.6 个月）中，从未检测到 SARS-CoV-2 RNA。2019 年 11 月至 2020 年 2 月期间。相反，2020 年 3 月至 4 月期间因毛细支气管炎住院的 2 名婴儿的 SARS-CoV-2 检测呈阳性。
结论
本研究不支持 SARS-CoV-2 在 SARS-CoV-2 感染正式爆发之前已在婴儿中传播的假设。然而，它首次表明 SARS-CoV-2 可能导致需要住院治疗的毛细支气管炎。
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