提出将有代表性的合成宏基因组包裹在单个酵母细胞中的想法。

Department of Genetics, Physiology and Microbiology, Complutense University of Madrid, Madrid, Spain.

Department of Molecular Sciences, and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, Australia.

Nat Commun. 2021 Mar 11;12(1):1599. doi: 10.1038/s41467-021-21877-y.

Synthetic metagenomics could potentially unravel the complexities of microbial ecosystems by revealing the simplicity of microbial communities captured in a single cell. Conceptionally, a yeast cell carrying a representative synthetic metagenome could uncover the complexity of multi-species interactions, illustrated here with wine ferments.

合成宏基因组学有可能通过揭示单个细胞中捕获的微生物群落的简单性来揭示微生物生态系统的复杂性。从概念上讲，携带代表性合成宏基因组的酵母细胞可以揭示多物种相互作用的复杂性，这里用葡萄酒发酵来说明这一点。