Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hypertens Res. 2021 Jul;44(7):850-857. doi: 10.1038/s41440-021-00636-y. Epub 2021 Mar 11.
Low ankle-brachial index (ABI) and high ABI difference (ABID) are each associated with poor prognosis. No study has assessed the ability of the combination of low ABI and high ABID to predict survival. We created an ABI score by assigning 1 point for ABI < 0.9 and 1 point for ABID ≥ 0.17 and examine the ability of this ABI score to predict mortality. We included 941 patients scheduled for echocardiographic examination. The ABI was measured using an ABI-form device. ABID was calculated as |right ABI-left ABI|. Among the 941 subjects, the prevalence of ABI < 0.9 and ABID ≥ 0.17 was 6.1% and 6.8%, respectively. Median follow-up to mortality was 93 months. There were 87 cardiovascular and 228 overall deaths. All ABI-related parameters, including ABI, ABID, ABI < 0.9, ABID ≥ 0.17, and ABI score, were significantly associated with overall and cardiovascular mortality in the multivariable analysis (P ≤ 0.009). Further, in the direct comparison of multivariable models, the basic model + ABI score was the best at predicting overall and cardiovascular mortality among the five ABI-related multivariable models (P ≤ 0.049). Hence, the ABI score, a combination of ABI < 0.9 and ABID ≥ 0.17, should be calculated for better mortality prediction.
踝臂指数（ABI）低和ABI 差值（ABID）高均与预后不良相关。尚无研究评估ABI 低值和 ABID 高值的组合对预测生存率的能力。我们创建了一个 ABI 评分，ABI<0.9 记 1 分，ABID≥0.17 记 1 分，并评估了该 ABI 评分预测死亡率的能力。共纳入 941 例行超声心动图检查的患者。ABI 使用 ABI-form 设备进行测量。ABID 计算为|右侧 ABI-左侧 ABI|。在 941 例患者中，ABI<0.9 和 ABID≥0.17 的患病率分别为 6.1%和 6.8%。中位随访至死亡时间为 93 个月。共有 87 例心血管死亡和 228 例全因死亡。在多变量分析中，所有 ABI 相关参数，包括 ABI、ABID、ABI<0.9、ABID≥0.17 和 ABI 评分，均与全因和心血管死亡率显著相关（P≤0.009）。此外，在对五个 ABI 相关多变量模型的直接比较中，基本模型+ABI 评分在预测全因和心血管死亡率方面优于其他四个模型（P≤0.049）。因此，ABI 评分（ABI<0.9 和 ABID≥0.17 的组合）应进行计算，以更好地预测死亡率。
