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回到未来:癌症免疫治疗使用检查点抑制剂后多肌痛和多肌痛样综合征的识别与分类

Back to the future: identification and classification of polymyalgia rheumatica and polymyalgia rheumatica-like syndromes following cancer immunotherapy with checkpoint inhibitors.

作者信息

Manzo Ciro, Isetta Marco

机构信息

Azienda Sanitaria Locale Napoli 3 sud, Internal and Geriatric Medicine Department, Rheumatologic Outpatient Clinic Hospital "Mariano Lauro", Sant'Agnello, Italy.

Library and Knowledge Services, Central and North West London NHS Foundation Trust, London, United Kingdom.

出版信息

Reumatologia. 2021;59(1):62-63. doi: 10.5114/reum.2021.102600. Epub 2021 Feb 28.

Abstract

Polymyalgia rheumatica (PMR) and PMR-like syndromes are among the most frequent rheumatologic immuno-related adverse events (IRAEs) induced by cancer immunotherapy with "checkpoint inhibitors" (ICIs). Our short communication addresses two key methodological issues laid bare by published literature : 1) how to diagnose PMR and PMR-like syndromes following ICI therapy, 2) how PMR/PMR-like syndromes following ICI therapy are described as adverse drug reactions (ADRs).

摘要

风湿性多肌痛(PMR)和类PMR综合征是癌症免疫疗法使用“检查点抑制剂”(ICI)引发的最常见的风湿性免疫相关不良事件(IRAEs)。我们的简短通讯探讨了已发表文献中暴露的两个关键方法学问题:1)ICI治疗后如何诊断PMR和类PMR综合征,2)ICI治疗后的PMR/类PMR综合征如何被描述为药物不良反应(ADR)。

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