Hegab Hany Mohamed, El-Ghammaz Amro Mohamed Sedky, El-Razzaz Mostafa Kamal, Helal Reham Ali Ali
Clinical Hematology and Bone Marrow Transplantation Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Internal Medicine, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Indian J Hematol Blood Transfus. 2021 Jan;37(1):37-44. doi: 10.1007/s12288-020-01315-7. Epub 2020 Jun 30.
Growth differentiation factor 15 (GDF15) plays an important role in cancer pathophysiology and prognosis. However, limited studies analyzed its level and prognostic value in acute myeloid leukemia (AML) patients. This study included 56 adult AML patients. Serum GDF15 level was measured at diagnosis in all patients by enzyme-linked immunosorbent assay. Remission and survival statuses were assessed at 90 days following treatment. GDF15 level was significantly higher in patients than in controls ( < 0.001). GDF15 level correlated positively with age ( < 0.001), hemoglobin level ( = 0.027), and platelet count ( = 0.024). High GDF15 above the median level was associated with inferior OS ( = 0.044) together with high platelet count ( = 0.006) and high bone marrow blast percent ( = 0.038). There was no statistically significant difference between patients with GDF15 above and below the median level regarding DFS (P = 0.881). On multivariate analysis for OS, GDF15 level was an independent risk factor ( = 0.047). In conclusion, serum GDF15 level is significantly elevated in AML patients and high GDF15 level is associated with inferior OS.
生长分化因子15（GDF15）在癌症病理生理学和预后中发挥重要作用。然而，分析其在急性髓系白血病（AML）患者中的水平和预后价值的研究有限。本研究纳入了56例成年AML患者。所有患者在诊断时通过酶联免疫吸附测定法测量血清GDF15水平。在治疗后90天评估缓解和生存状态。患者的GDF15水平显著高于对照组（<0.001）。GDF15水平与年龄（<0.001）、血红蛋白水平（=0.027）和血小板计数（=0.024）呈正相关。高于中位数水平的高GDF15与较差的总生存期（OS）（=0.044）以及高血小板计数（=0.006）和高骨髓原始细胞百分比（=0.038）相关。GDF15高于和低于中位数水平的患者之间的无病生存期（DFS）无统计学显著差异（P=0.881）。在OS的多因素分析中，GDF15水平是一个独立危险因素（=0.047）。总之，AML患者的血清GDF15水平显著升高，高GDF15水平与较差的OS相关。
