Gupta Dhiren, Dhingra Sandeep
Division of Pediatric Emergency and Critical Care, Department of Pediatrics, Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India.
Department of Pediatrics, Command Hospital, Panchkula, Haryana, India.
Indian J Crit Care Med. 2021 Feb;25(2):123-125. doi: 10.5005/jp-journals-10071-23745.
Hemodynamic monitoring and categorization of patients based on fluid responsiveness is the key to decisions prompting the use of fluids and vasoactive agents in septic shock. Distinguishing patients who are going to benefit from fluids from those who will not is of paramount importance as large amounts of fluids used conventionally based on surviving sepsis guidelines may be detrimental. Noninvasive monitoring techniques for the assessment of various cardiovascular parameters are increasingly accepted as the current medical practice. Electrical cardiometry (EC) is one such method for the determination of stroke volume, cardiac output (CO), and other hemodynamic parameters and is based on changes in electrical conductivity within the thorax. It has been validated against gold standard methods such as thermodilution [Malik V, Subramanian A, Chauhan S, et al. World J 2014;4(7):101-108] and is being used more often as a point-of-care noninvasive technique for hemodynamic monitoring. EC is Food and Drug Administration approved and validated for use in neonates, children, and adults. A meta-analysis in 2016, including 20 studies and 624 patients comparing the accuracy of CO measurement by using EC with other noninvasive technologies, demonstrated that EC was the device that offered the most correct measurements. The article in the current issue of by Rao et al. (2020) has extended the use of EC to categorize pediatric patients with septic shock into vasodilated and vasoconstricted states based on systemic vascular resistance and correlate the categorization clinically. The authors also studied the changes in hemodynamic parameters after an isotonic fluid bolus of 20 mL/kg was administered. This is a pilot prospective observational study of 30 patients, which has given an insight into physiological rearrangements following fluid administration in patients with septic shock. Gupta D, Dhingra. Electrocardiometry Fluid Responsiveness in Pediatric Septic Shock. Indian J Crit Care Med 2021;25(2):123-125.
基于液体反应性对患者进行血流动力学监测和分类是决定在感染性休克中使用液体和血管活性药物的关键。区分哪些患者能从补液中获益,哪些患者不能,这至关重要,因为按照脓毒症存活指南常规使用大量液体可能有害。用于评估各种心血管参数的非侵入性监测技术日益被当前医学实践所接受。心电描记法(EC)就是一种用于测定每搏输出量、心输出量(CO)及其他血流动力学参数的方法,它基于胸部电导率的变化。该方法已通过与热稀释法等金标准方法进行验证[马利克V、苏布拉马尼亚姆A、乔汉S等。《世界杂志》2014年;4(7):101 - 108],并且作为一种即时非侵入性血流动力学监测技术被更频繁地使用。EC已获得美国食品药品监督管理局批准并验证可用于新生儿、儿童和成人。2016年的一项荟萃分析纳入了20项研究和624名患者,比较了使用EC与其他非侵入性技术测量CO的准确性,结果表明EC是测量最准确的设备。饶等人(2020年)在本期发表的文章将EC的应用扩展到根据体循环血管阻力对感染性休克的儿科患者进行血管舒张和血管收缩状态分类,并将分类与临床情况相关联。作者还研究了给予20 mL/kg等渗液体推注后血流动力学参数的变化。这是一项针对30名患者的前瞻性观察性初步研究,它让我们深入了解了感染性休克患者补液后生理上的重新调整。古普塔D、丁格拉。《儿科感染性休克的心电描记法液体反应性》。《印度危重症医学杂志》2021年;25(2):123 - 125。