Ren Fu-Jia, Yao Yao, Cai Xiao-Yu, Fang Guo-Ying
Department of Pharmacy, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China.
Department of Pharmacy, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, China.
Front Pharmacol. 2021 Feb 23;12:614068. doi: 10.3389/fphar.2021.614068. eCollection 2021.
MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in numerous biological processes by regulating the post-transcriptional expression of target genes. Recent studies have demonstrated that miR-192-5p, a member of the miR-192 family, partakes in several human diseases, especially various cancers, including cancers of the lung, liver, and breast. Importantly, the levels of miR-192-5p are abundant in biofluids, including the serum and urine, and the exosomal levels of miR-192-5p in circulation can aid in the diagnosis and prognosis of various diseases, such as chronic hepatitis B (CHB) infection disease. Notably, recent studies suggest that miR-192-5p is regulated by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). However, there are no comprehensive overviews on the role of miR-192-5p in human diseases. This review discusses the significant studies on the role of miR-192-5p in various human diseases, with special emphasis on the diseases of the respiratory and digestive systems.
微小RNA（miRNA）是一类小的非编码RNA，通过调控靶基因的转录后表达在众多生物学过程中发挥重要作用。最近的研究表明，miR-192-5p作为miR-192家族的一员，参与多种人类疾病，尤其是各种癌症，包括肺癌、肝癌和乳腺癌。重要的是，miR-192-5p在生物流体（包括血清和尿液）中含量丰富，循环中外泌体miR-192-5p水平有助于各种疾病的诊断和预后，如慢性乙型肝炎（CHB）感染疾病。值得注意的是，最近的研究表明miR-192-5p受长链非编码RNA（lncRNA）和环状RNA（circRNA）调控。然而，目前尚无关于miR-192-5p在人类疾病中作用的全面综述。本综述讨论了关于miR-192-5p在各种人类疾病中作用的重要研究，特别强调了呼吸系统和消化系统疾病。
