Norup Thomsen Cecilie, Sperling Søren, Fledelius Joan, Gjørup Pia Holland
Department of Internal Medicine, Holstebro Regional Hospital, Hospital Unit West, Holstebro, Denmark.
Department of Nuclear Medicine & PET- Centre, Herning Regional Hospital, Hospital Unit West, Herning, Denmark.
Eur Clin Respir J. 2021 Feb 24;8(1):1882030. doi: 10.1080/20018525.2021.1882030.
We herein report a rare case that describes and visualizes nocardiosis in a patient with diabetes. The patient presented with recurring fever, gout, leg pain, frailty and muscular pain through nine months, before a core needle biopsi, from an abscess in the abdominal musculature, revealed Nocardia Paucivorans. A PET-CT-scan showed multiple muscular FDG-positive sites. Furthermore, he experienced serious side effects to Sulfametoxazole and Trimethoprim, the antibiotic of choice for this type of infection. He was then switched to Moxifloxacin and Ampicillin. Nocardia often presents as opportunistic infections, typically in patients with severe immunodeficiencies, such as HIV, use of high-dose corticosteroids, hematologic malignancies or immunosuppression following organ transplantation. This case illustrates how a patient with only relative immunodeficiency gets rare nocardiosis. Our sparse knowledge on clinical presentation is based on case-reports and treatment is empirical. Hence, a better understanding of the clinical presentation and treatment is important. Especially given the prospect, that the health care system faces a greater load of patients with diabetes and other immunodeficiencies in the future.
我们在此报告一例罕见病例,该病例描述并呈现了一名糖尿病患者的诺卡菌病。该患者在腹部肌肉组织脓肿进行粗针活检显示少动诺卡菌之前的九个月里,反复出现发热、痛风、腿痛、身体虚弱和肌肉疼痛症状。正电子发射断层扫描-计算机断层扫描(PET-CT)显示多个肌肉部位氟脱氧葡萄糖(FDG)呈阳性。此外,他对磺胺甲恶唑和甲氧苄啶(这种感染的首选抗生素)出现了严重的副作用。随后他改用莫西沙星和氨苄西林。诺卡菌通常表现为机会性感染,典型情况是在患有严重免疫缺陷的患者中,如感染人类免疫缺陷病毒(HIV)、使用大剂量皮质类固醇、血液系统恶性肿瘤或器官移植后的免疫抑制患者。该病例说明了仅有相对免疫缺陷的患者如何患上罕见的诺卡菌病。我们对临床表现的了解稀少,基于病例报告且治疗是经验性的。因此,更好地了解临床表现和治疗方法很重要。特别是考虑到未来医疗保健系统将面临更多糖尿病和其他免疫缺陷患者的情况。