Shah Munjal, Gadia Akshay, Nene Abhay, Patel Priyank
Department of Spine Surgery, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.
Asian J Neurosurg. 2020 Dec 21;15(4):1011-1015. doi: 10.4103/ajns.AJNS_290_20. eCollection 2020 Oct-Dec.
Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor. Primary or metastatic involvement of the spine is unusual in ASPS. In most case, it is refractory to chemotherapy and radiation. Surgical resection is the most effective intervention. We report the case of a 38-year-old female having ASPS along with metastatic spine and hip involvement treated surgically as a single-stage operation, which is the first of its kind approach to our knowledge. We present the case of a 38-year-old female with simultaneous L4 pathological fracture with symptomatic lumbar canal stenosis without focal neurology and pathological fracture of neck of femur of left hip, secondary to metastatic ASPS. Since both conditions were contributing equally to her disability and demanded early intervention, they were treated simultaneously with intralesional excision of the tumor and posterior stabilization of the spine and left hip proximal femur resection and replaced it with proximal femur endoprosthesis as a single-stage operation. Postoperatively, she had significant relief of radiculopathy and left hip pain. She was mobilized out of bed on the postoperative day 1 and was discharged from hospital on the postoperative day 6. She was given chemotherapy drug sunitib postoperative. At her last follow-up, 20 months' postoperative, she was asymptomatic and was independent in terms of activities of daily living. Metastatic ASPS of the spine and hip is a rare clinical entity. Simultaneous surgical treatment of the spine and hip pathology is technically demanding. If the conditions demands, as in our case, both of them can be managed safely in a single-stage with good midterm outcome.
肺泡软组织肉瘤(ASPS)是一种罕见的软组织肿瘤。脊柱的原发性或转移性受累在ASPS中并不常见。在大多数情况下,它对化疗和放疗均不敏感。手术切除是最有效的干预措施。我们报告了一例38岁女性患有ASPS并伴有脊柱和髋部转移,通过一期手术进行了手术治疗,据我们所知,这是首例此类手术方法。我们介绍了一例38岁女性,因转移性ASPS继发L4病理性骨折并伴有有症状的腰椎管狭窄但无局灶性神经病变以及左髋股骨颈病理性骨折。由于这两种情况对她的残疾程度影响相同且都需要早期干预,因此通过肿瘤内切除、脊柱后路稳定以及左髋近端股骨切除并置换为近端股骨假体进行一期手术同时治疗这两种情况。术后,她的神经根病和左髋疼痛明显缓解。术后第1天她即可下床活动,术后第6天出院。术后给予她化疗药物舒尼替尼。在术后20个月的最后一次随访中,她无症状且日常生活活动能够自理。脊柱和髋部的转移性ASPS是一种罕见的临床病症。同时对脊柱和髋部病变进行手术治疗在技术上要求较高。如果情况需要,如我们的病例所示,两者可以在一期手术中安全地进行处理,并取得良好的中期效果。