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老年营养风险指数与中国老年人骨密度的关系。

Association between geriatric nutrition risk index and bone mineral density in elderly Chinese people.

机构信息

Department of Endocrinology, ZhuJiang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China.

Department of Gerontology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai City, Guangdong Province, China.

出版信息

Arch Osteoporos. 2021 Mar 11;16(1):55. doi: 10.1007/s11657-020-00862-w.

Abstract

UNLABELLED

Malnutrition contributes to the occurrence of osteoporosis. This study showed that participants with higher GNRI values had higher levels of BMD. GNRIs were positively correlated with BMD and independently associated with total hip T-score. GNRIs may be a good indicator for identifying elderly who need further bone health nutritional support.

PURPOSE

To evaluate the relationship between geriatric nutrition risk index (GNRI) and bone mineral density (BMD) in elderly Chinese people.

METHODS

We recruited 1130 older adults (60-89 years old) between May 2018 and December 2019. Participants underwent clinical, laboratory, and densitometry examinations. Dual-energy x-ray absorptiometry densitometers and corresponding software were used to assess the BMD and T-scores of participants. Differences between study groups were assessed using one-way analysis of variance (ANOVA) for continuous variables and the chi-square test for categorical variables. Pearson's correlation coefficient was used to assess the correlation between two variables. Multivariate linear regressions with or without adjustments were constructed to explore the possible confounding variables.

RESULTS

Individuals with higher GNRI values had higher total hip and lumbar spine T-scores (P < 0.001, P = 0.029, respectively). Pearson's correlation demonstrated that GNRIs were positively correlated with BMD at different anatomical sites, in both sexes but especially in women. A multiple regression demonstrated that GNRIs were independently associated with total hip T-score in both sexes (β = 0.111 for men and 0.174 for women; P = 0.034 and 0.008, respectively).

CONCLUSIONS

Elderly people with higher GNRI values had higher total hip and lumbar spine T-scores, which suggested that GNRI is closely related to BMD. This relationship is maintained at the total hip, even after fully adjusting for possible confounding variables, and consequently, it may be a good indicator for identifying older people who need further bone health nutritional support.

摘要

不具名

营养不良会导致骨质疏松症的发生。本研究表明,GNRI 值较高的参与者具有更高的骨密度水平。GNRIs 与 BMD 呈正相关,且与全髋 T 评分独立相关。GNRIs 可能是识别需要进一步骨骼健康营养支持的老年人的良好指标。

目的

评估老年营养风险指数(GNRI)与中国老年人骨密度(BMD)之间的关系。

方法

我们招募了 1130 名年龄在 60-89 岁之间的老年人(2018 年 5 月至 2019 年 12 月)。参与者接受了临床、实验室和骨密度仪检查。双能 X 射线吸收仪及其配套软件用于评估参与者的 BMD 和 T 评分。使用单因素方差分析(ANOVA)评估连续变量组间差异,使用卡方检验评估分类变量组间差异。使用 Pearson 相关系数评估两个变量之间的相关性。构建多元线性回归模型,分别进行或不进行调整,以探讨可能的混杂变量。

结果

GNRI 值较高的个体具有更高的全髋和腰椎 T 评分(P<0.001,P=0.029)。Pearson 相关分析表明,GNRIs 与不同解剖部位的 BMD 呈正相关,且在男女两性中均如此,但在女性中更为显著。多元回归分析表明,GNRIs 与两性的全髋 T 评分独立相关(男性的β=0.111,女性的β=0.174;P=0.034 和 0.008)。

结论

GNRI 值较高的老年人具有更高的全髋和腰椎 T 评分,提示 GNRI 与 BMD 密切相关。这种相关性在全髋部位仍然存在,即使在充分调整了可能的混杂变量后也是如此,因此,它可能是识别需要进一步骨骼健康营养支持的老年人的良好指标。

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