Department of Nephrology, Huadong Hospital affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China.
Shanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China.
Arch Osteoporos. 2020 Jun 18;15(1):90. doi: 10.1007/s11657-020-00764-x.
Renal tubule cells play a pivotal role in maintaining bone homeostasis. Hence, renal tubular function may be associated with bone mineral density. Our study found that urinary β microglobulin-creatinine ratio (UBCR) levels correlated negatively with lumbar spine bone mineral density (BMD) and T and Z values, and may be a marker for osteoporosis in Chinese elderly male adults.
To study the association of UBCR levels with BMD and the predictive value of UBCR for osteoporosis in elderly Chinese male adults.
A cross-sectional study of 149 (65 to 85 years, 69.7 ± 4.6) Chinese male adults who underwent health checkups in Huadong Hospital in Shanghai China was conducted. BMD was measured by dual-energy X-ray absorptiometry. The clinical variables and BMD of the participants in the low UBCR group (B1, UBCR < 300 μg/g) and the high UBCR group (B2, UBCR ≥ 300 μg/g) were compared. Associations between UBCR with clinical variables and BMD were analyzed by Pearson's correlation coefficient and multiple regression analysis. BMD and T and Z values were compared between the B1 and B2 groups. The odds ratios (ORs) for dose-dependent increases in osteoporosis between B1 and B2 were analyzed by binary logistic regression analysis. The area under the receiver operating characteristic (ROC) curve was used to analyze the capacity of UBCR to predict osteoporosis.
UBCR was significantly higher in the osteoporosis group. After adjusting for multiple confounders, UBCR levels correlated negatively with BMD and T and Z values of the lumbar spine. Lumbar spine BMD and T and Z values were significantly lower in the B2 UBCR group than in the B1 UBCR group. Compared with the B1 participants, the ORs for "osteoporosis" were 12.401 times higher in B2 participants (P = 0.005) by binary logistic regression analysis after adjusting for potential confounders. The UBCR index (cutoff = 362.48 μg/g) had a sensitivity of 78.6% and a specificity of 68.7% for identifying osteoporosis, with an area under the ROC curve of 0.760.
These results suggest that UBCR levels correlate negatively with lumbar spine BMD and T and Z values and may serve as a marker for osteoporosis in Chinese elderly male adults.
研究尿 β 微球蛋白/肌酐比值（UBCR）与骨密度的相关性，以及 UBCR 对中国老年男性骨质疏松症的预测价值。
采用横断面研究方法，对 149 名（65~85 岁，69.7±4.6 岁）在上海华东医院进行健康体检的中国老年男性进行研究。采用双能 X 线吸收法测定骨密度。比较 UBCR 低值组（B1，UBCR<300μg/g）和 UBCR 高值组（B2，UBCR≥300μg/g）参与者的临床变量和骨密度。采用 Pearson 相关系数和多元回归分析 UBCR 与临床变量和骨密度的相关性。比较 B1 和 B2 组之间 BMD 和 T 值、Z 值的差异。采用二元逻辑回归分析 B1 和 B2 组之间骨质疏松症发生率的剂量依赖性增加的比值比（OR）。采用受试者工作特征（ROC）曲线下面积分析 UBCR 预测骨质疏松症的能力。
骨质疏松组 UBCR 明显升高。校正多个混杂因素后，UBCR 水平与腰椎骨密度和 T 值、Z 值呈负相关。B2 UBCR 组腰椎骨密度和 T 值、Z 值明显低于 B1 UBCR 组。与 B1 组参与者相比，在校正潜在混杂因素后，B2 组参与者患“骨质疏松症”的 OR 为 12.401 倍（P=0.005）。UBCR 指数（截断值=362.48μg/g）对骨质疏松症的识别具有 78.6%的敏感性和 68.7%的特异性，ROC 曲线下面积为 0.760。
这些结果表明，UBCR 水平与腰椎骨密度和 T 值、Z 值呈负相关，可作为中国老年男性骨质疏松症的标志物。
