CLCC Eugène Marquis, Inserm, LTSI - UMR 1099, Univ Rennes, CHU Rennes, 2 Av. du Professeur Léon Bernard, 35000, Rennes, France.
MAGMA. 2021 Oct;34(5):729-740. doi: 10.1007/s10334-020-00901-0. Epub 2021 Mar 12.
MRI is a reliable and accurate technique to characterize rheumatoid arthritis. The aim of this study was to provide voxel-by-voxel 3D maps of the proton density fat fraction (PDFF), the T of water (T), the T of fat (T), the T* of water (T*), the T* of fat (T*) in the wrist bone marrow.
The experiments were conducted on 14 healthy volunteers (mean age: 24 ± 4). The data were acquired at 1.5 T using two optimized four-echo 3D 1.2 × 1.2 × 1.2 mm-isotropic spoiled gradient sequences. A repeatability study was carried out. The measurements were done using a homemade parametric viewer software.
The inter-volunteer results were, on average: PDFF = 86 ± 3%, T = 441 ± 113 ms, T = 245 ± 19 ms, T* = 6 ± 1 ms and T* = 16 ± 3 ms. The coefficients of variation were for fat based biomarkers CV < 5%, CV < 15% and CV < 10% in the repeatability study.
The protocol and quantification tool proposed in this study provide high-resolution voxel-by-voxel 3D maps of five biomarkers in the wrist in less than 4 min of acquisition.
MRI 是一种可靠且准确的技术，可用于类风湿关节炎的特征分析。本研究的目的是提供腕骨骨髓质子密度脂肪分数（PDFF）、水 T1（T）、脂肪 T1（T）、水 T2（T）、脂肪 T2（T）的体素级 3D 图谱。
本实验在 14 名健康志愿者（平均年龄：24±4 岁）中进行。在 1.5 T 下使用两个优化的四回波 3D 1.2×1.2×1.2mm 各向同性扰相梯度序列进行实验。进行了重复性研究。使用自制的参数化视图软件进行测量。
志愿者间的平均结果为：PDFF=86±3%，T=441±113ms，T=245±19ms，T*=6±1ms 和 T*=16±3ms。在重复性研究中，基于脂肪的生物标志物的变异系数 CV<5%，CV<15%和 CV<10%。
本研究中提出的方案和量化工具在不到 4 分钟的采集时间内提供了腕部五个生物标志物的高分辨率体素级 3D 图谱。
