克拉维酸对临床厌氧菌对替卡西林敏感性的影响：一项多中心研究。
Effect of clavulanic acid on the susceptibility of clinical anaerobic bacteria to ticarcillin: a multicenter study.
作者信息
Fuchs P C, Jones R N, Barry A L, Allen S D, Aldridge K E, Gerlach E H, Sommers H M
机构信息
Department of Pathology, St. Vincent Hospital and Medical Center, Portland, OR 97225.
出版信息
Diagn Microbiol Infect Dis. 1988 Jan;9(1):47-50. doi: 10.1016/0732-8893(88)90060-0.
Over 2,000 recent clinical isolates of anaerobic bacteria were tested at five medical centers for susceptibility to ticarcillin, ticarcillin plus clavulanic acid, clindamycin, and metronidazole. At 64 micrograms/ml, ticarcillin inhibited 92% of all isolates, but 98% were inhibited at this concentration when 2 micrograms/ml of clavulanic acid was added. With different Bacteroides species, clavulanic acid reduced ticarcillin MICs 2- to 32-fold; other anaerobic species were not significantly affected.
在五个医疗中心对2000多株近期分离出的厌氧菌临床菌株进行了替卡西林、替卡西林加克拉维酸、克林霉素和甲硝唑的药敏试验。在64微克/毫升时，替卡西林抑制了所有菌株的92%，但当加入2微克/毫升克拉维酸时，该浓度下98%的菌株被抑制。对于不同的拟杆菌属菌种，克拉维酸使替卡西林的最低抑菌浓度（MIC）降低了2至32倍；其他厌氧菌不受显著影响。
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