替卡西林加克拉维酸对632株临床分离株的体外活性
In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates.
作者信息
Fuchs P C, Barry A L, Thornsberry C, Jones R N
出版信息
Antimicrob Agents Chemother. 1984 Mar;25(3):392-4. doi: 10.1128/AAC.25.3.392.
Abstract
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions of ticarcillin alone and in combination with 1, 2, and 4 micrograms of clavulanic acid (CA) (Timentin) per ml by a reference microdilution method. With the addition of CA, ticarcillin MICs were reduced eightfold or greater with 54 of 59 (92%) strains of the family Enterobacteriaceae with ticarcillin MICs of greater than or equal to 64 micrograms/ml. The inhibitory effect of CA on pseudomonads was minimal. Ticarcillin MICs for beta-lactamase-producing Haemophilus influenzae, Neisseria gonorrhoeae, and most Staphylococcus aureus were reduced to less than or equal to 0.5 micrograms/ml when CA was added. For dilution susceptibility testing of ticarcillin-clavulanic acid, dilutions of ticarcillin combined with 2 micrograms of CA per ml is suggested.
摘要
采用参考微量稀释法，对总共632株临床分离细菌进行了测试，以检测其对单独的替卡西林以及与每毫升1、2和4微克克拉维酸（CA）（替门汀）联合使用时两倍稀释液的敏感性。加入CA后，对于59株（92%）替卡西林最低抑菌浓度（MIC）大于或等于64微克/毫升的肠杆菌科菌株中的54株，替卡西林的MIC降低了八倍或更多。CA对假单胞菌的抑制作用极小。当加入CA时，产β-内酰胺酶的流感嗜血杆菌、淋病奈瑟菌和大多数金黄色葡萄球菌的替卡西林MIC降低至小于或等于0.5微克/毫升。对于替卡西林-克拉维酸的稀释敏感性测试，建议使用每毫升含2微克CA的替卡西林稀释液。
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