Division of Minimally Invasive Surgery, Center for the Future of Surgery, University of California San Diego, San Diego, California, USA.
J Laparoendosc Adv Surg Tech A. 2022 Feb;32(2):111-117. doi: 10.1089/lap.2020.0792. Epub 2021 Mar 11.
Paraesophageal hernias readily affect the elderly with a median age of presentation between 65 and 75 years. Laparoscopic paraesophageal hernia repair (PEHR) is a technically challenging operation with potential for dire complications. Advanced age and medical comorbidities may heighten perioperative risk and limit surgical candidacy, potentially refusing patients an opportunity toward symptom resolution. Given the increased prevalence in the elderly and associated surgical risks, we aim to assess age as an independent risk factor for perioperative morbidity and mortality after PEHR. A retrospective analysis using a prospectively maintained database assessed patients undergoing PEHR from 2007 to 2018. Patients were stratified by age: Group A (age <65 years), Group B (65≤ age <80 years), and Group C (age ≥80 years). Patient demographics, preoperative symptoms, postoperative outcomes, and mortality rate were analyzed. Barium esophagram was performed on symptomatic postsurgical patients. Recurrence was confirmed radiologically. In total, 143 patients underwent laparoscopic (94.4%) or robotic-assisted (5.6%) PEHR. Average age per group was Group A ( = 49) 55.4 years (standard deviation [SD] ±8.91), Group B ( = 76) 71.4 years (SD ±4.40), and Group C ( = 17) 84.1 (years) (SD ±3.37). Group C had significantly higher rates of nonelective surgery ( = .018), preoperative weight loss ( = .014), hypertension ( = .031), ischemic heart disease ( = .001), and cancer ( = .039); preoperative body mass index was significantly lower ( = .048). Charlson comorbidity index differences between groups were significant (2.00 versus 3.61 versus 5.28, < .001). Median follow-up was 426 days (6-3199). Symptom improvement was seen in 78.3% of patients. Recurrence and reoperation rates were not significantly different between groups. No differences were seen in mortality, length of stay, or postoperative complications between groups. PEHR in elderly patients proved to be safe and effective. Avoidance of emergent intervention may be achieved through a judicious elective approach to this anatomic problem. Symptom resolution and quality-of-life improvement can be safely achieved with surgical repair in this patient population, demonstrating that age is truly just a number for PEHR.
食管裂孔疝容易影响老年人,其发病中位年龄在 65 至 75 岁之间。腹腔镜食管裂孔疝修补术(PEHR)是一项技术上具有挑战性的手术,可能会出现严重的并发症。高龄和合并症可能会增加围手术期风险,并限制手术适应证,使患者无法获得症状缓解的机会。鉴于老年人患病率增加和相关手术风险,我们旨在评估年龄是否为 PEHR 围手术期发病率和死亡率的独立危险因素。
本研究使用前瞻性维护的数据库进行回顾性分析,评估了 2007 年至 2018 年间接受 PEHR 的患者。患者按年龄分层:A 组(年龄<65 岁)、B 组(65≤年龄<80 岁)和 C 组(年龄≥80 岁)。分析患者的人口统计学资料、术前症状、术后结果和死亡率。对有症状的术后患者行钡餐食管造影检查。通过影像学检查确认复发。
共有 143 例患者接受了腹腔镜(94.4%)或机器人辅助(5.6%)PEHR。每组的平均年龄分别为 A 组( = 49)55.4 岁(标准差[SD]±8.91)、B 组( = 76)71.4 岁(SD±4.40)和 C 组( = 17)84.1 岁(SD±3.37)。C 组无选择性手术( = .018)、术前体重减轻( = .014)、高血压( = .031)、缺血性心脏病( = .001)和癌症( = .039)的发生率明显更高;术前体重指数明显更低( = .048)。各组间Charlson 合并症指数差异有统计学意义(2.00 与 3.61 与 5.28, < .001)。中位随访时间为 426 天(6-3199)。78.3%的患者症状改善。各组间复发和再次手术率无显著差异。各组间死亡率、住院时间和术后并发症无差异。
在老年患者中,PEHR 是安全有效的。通过明智地选择择期手术方法,可避免紧急干预。在这一患者人群中,手术修复可安全实现症状缓解和生活质量改善,表明年龄确实只是 PEHR 的一个数字。