绿色合成非贵金属掺杂的铜氢氧化物纳米粒子用于构建多巴胺传感器。
Green synthesis of nonprecious metal-doped copper hydroxide nanoparticles for construction of a dopamine sensor.
机构信息
Department of Chemistry, Electrochemical Sensors Research Laboratory, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, PO Box 1678815811, Tehran, Iran.
Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, PO Box 1678815811, Tehran, Iran.
出版信息
Future Med Chem. 2021 Apr;13(8):715-729. doi: 10.4155/fmc-2020-0333. Epub 2021 Mar 12.
Copper oxide nanoparticles doped with nonprecious metal species (Ni and Mn) were synthesized. A glassy carbon electrode (GCE) was modified by drop-casting of nanostructure suspensions, constructing Ni:Cu(OH)/GCE, Mn:Cu(OH)/GCE and Cu(OH)/GCE. The voltammetric oxidation of dopamine (DA) by the constructed electrodes confirmed that the electrocatalytic oxidation of DA is a reversible, pH-dependent, diffusion-controlled process; the best response was obtained by Mn:Cu(OH)/GCE. A sensitive calibration graph (0.664 μA/μM) was produced for DA in the concentration range of 0.3-10.0 μM, with a detection limit of 79 nM using Mn:Cu(OH)/GCE. The Mn:Cu(OH)/GCE possessed an accurate response toward DA with an acceptable selectivity, stability and antifouling effect, revealing the applicability of the Mn:Cu(OH)/GCE for DA analysis in biological samples.
合成了掺杂非贵金属物种（Ni 和 Mn）的氧化铜纳米粒子。通过滴铸纳米结构悬浮液对玻碳电极（GCE）进行修饰，构建了 Ni:Cu(OH)/GCE、Mn:Cu(OH)/GCE 和 Cu(OH)/GCE。通过构建的电极对多巴胺（DA）的伏安氧化证实，DA 的电化学氧化是一个可逆的、依赖于 pH 值的、扩散控制的过程；Mn:Cu(OH)/GCE 得到了最佳的响应。Mn:Cu(OH)/GCE 对 0.3-10.0 μM 范围内的 DA 产生了敏感的校准曲线（0.664 μA/μM），检测限为 79 nM。Mn:Cu(OH)/GCE 对 DA 具有准确的响应，具有可接受的选择性、稳定性和抗污染性，表明 Mn:Cu(OH)/GCE 适用于生物样品中 DA 的分析。
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