棉酚的发育毒性评估。
A developmental toxicity evaluation of gossypol.
作者信息
Beaudoin A R
机构信息
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109.
出版信息
Contraception. 1988 Feb;37(2):197-219. doi: 10.1016/0010-7824(88)90131-x.
In utero development was analyzed in pregnancies that resulted from matings between gossypol-treated male rats and untreated female rats, and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy. There was no significant effect on resorption, fetal growth, or malformation rate. Similarly, gossypol administered to pregnant dams at stages during organogenesis had no observable effect on pregnancy. Under the conditions of this experiment, gossypol administered to either the breeding male rat or the pregnant female rat had no demonstrable adverse effect on development in utero.
对棉酚处理的雄性大鼠与未处理的雌性大鼠交配所产生的妊娠以及仅对妊娠大鼠给予棉酚的妊娠中的子宫内发育进行了分析。对雄性大鼠进行棉酚处理对妊娠结局没有影响。对吸收、胎儿生长或畸形率没有显著影响。同样，在器官发生阶段对妊娠母鼠给予棉酚对妊娠没有可观察到的影响。在本实验条件下，对繁殖雄性大鼠或妊娠雌性大鼠给予棉酚对子宫内发育没有明显的不良影响。
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